Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain.
Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain.
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DOI：
10.1038/s41467-023-36093-z
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发表时间：
2023-02-08
影响因子：
16.6
通讯作者：
Tang, Peifu
中科院分区：
文献类型：
--
作者：
Chen, Chao;Sun, Linlin;Adler, Avital;Zhou, Hang;Zhang, Licheng;Zhang, Lihai;Deng, Junhao;Bai, Yang;Zhang, Jinhui;Yang, Guang;Gan, Wen-Biao;Tang, Peifu
Increased low frequency cortical oscillations are observed in people with neuropathic pain, but the cause of such elevated cortical oscillations and their impact on pain development remain unclear. By imaging neuronal activity in a spared nerve injury (SNI) mouse model of neuropathic pain, we show that neurons in dorsal root ganglia (DRG) and somatosensory cortex (S1) exhibit synchronized activity after peripheral nerve injury. Notably, synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations. This DRG synchrony is initiated by axotomized neurons and mediated by local purinergic signaling at the site of nerve injury. We further show that synchronized DRG activity after SNI is responsible for increasing low frequency cortical oscillations and synaptic remodeling in S1, as well as for inducing animals’ pain-like behaviors. In naive mice, enhancing the synchrony, not the level, of DRG neuronal activity causes synaptic changes in S1 and pain-like behaviors similar to SNI mice. Taken together, these results reveal the critical role of synchronized DRG neuronal activity in increasing cortical plasticity and oscillations in a neuropathic pain model. These findings also suggest the potential importance of detection and suppression of elevated cortical oscillations in neuropathic pain states. Increased low frequency cortical oscillations are observed in neuropathic pain. Here the authors perform Ca2+ imaging of DRG sensory neurons in a mouse model of neuropathic pain, and show that synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations are observed.
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细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
3.7
作者：
Pinheiro ES;de Queirós FC;Montoya P;Santos CL;do Nascimento MA;Ito CH;Silva M;Nunes Santos DB;Benevides S;Miranda JG;Sá KN;Baptista AF
通讯作者：
Baptista AF
影响因子：
5.5
作者：
Allene, Camille;Cossart, Rosa
通讯作者：
Cossart, Rosa
影响因子：
3
作者：
Cichon, Joseph;Magrane, Jordi;Gan, Wen-Biao
通讯作者：
Gan, Wen-Biao
影响因子：
13.9
作者：
Costigan M;Scholz J;Woolf CJ
通讯作者：
Woolf CJ