Physical activity and breast cancer risk among pre- and postmenopausal women in the U.S. Radiologic Technologists cohort.
Physical activity and breast cancer risk among pre- and postmenopausal women in the U.S. Radiologic Technologists cohort.
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DOI：
10.1007/s10552-008-9246-2
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发表时间：
2009-04
影响因子：
2.3
通讯作者：
Freedman, D. Michal
中科院分区：
文献类型：
--
作者：
Howard, Regan A.;Leitzmann, Michael F.;Linet, Martha S.;Freedman, D. Michal
阐明体力活动与乳腺癌之间关联的各个方面，例如所需的活动强度，以及更年期激素疗法 (MHT) 使用等因素可能导致的效果改变。我们前瞻性地研究了参与美国放射技术专家队列的 45,631 名女性的体力活动与乳腺癌风险的关系。参与者提供了基线信息，包括每周从事剧烈活动、步行/远足锻炼以及在家或工作中步行的时间。我们使用 Cox 回归估计了乳腺癌的多变量相对风险 (RR) 和 95% 置信区间 (CI)。我们发现了 864 例浸润性乳腺癌。与报告没有步行/徒步旅行的女性相比，每周步行/徒步旅行运动 10 小时或以上的女性风险降低幅度最大（RR，0.57；95%CI，0.34-0.95）。 MHT 的使用改变了步行/徒步旅行与乳腺癌之间的关联（交互作用 p=0.039）。从未使用过 MHT 的绝经后女性患乳腺癌的风险与体力活动有关，但在曾经使用过 MHT 的女性中却没有观察到这种关系。我们的研究表明，中等强度的体力活动（例如步行）可以预防乳腺癌。此外，体力活动与乳腺癌之间的关系可能会通过 MHT 的使用而改变。
To clarify aspects of the association between physical activity and breast cancer, such as activity intensity required, and possible effect modification by factors such as menopausal hormone therapy (MHT) use. We prospectively examined physical activity in relation to breast cancer risk among 45,631 women participating in the U.S. Radiologic Technologists cohort. Participants provided information at baseline regarding hours spent per week engaging in strenuous activity, walking/hiking for exercise, and walking at home or work. We estimated multivariable relative risks (RR) and 95% confidence intervals (CI) of breast cancer using Cox regression. We identified 864 incident invasive breast cancers. Greatest risk reduction was observed among women who reported walking/hiking for exercise 10 or more hours per week (RR, 0.57;95%CI, 0.34-0.95) compared with those reporting no walking/hiking. The association between walking/hiking for exercise and breast cancer was modified by MHT use (p for interaction=0.039). Postmenopausal women who never used MHT had reduced risks of breast cancer associated with physical activity whereas no relation was observed among ever users of MHT. Our study suggests moderate intensity physical activity, such as walking, may protect against breast cancer. Further, the relation between physical activity and breast cancer may be modified by MHT use.
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影响因子：
5
作者：
Bowles, HR;Fitzgerald, SJ;Blair, SN
通讯作者：
Blair, SN
影响因子：
3.2
作者：
Hagstromer, Maria;Oja, Pekka;Sjostrom, Michael
通讯作者：
Sjostrom, Michael
影响因子：
2.3
作者：
MITTENDORF, R;LONGNECKER, MP;WILLETT, WC
通讯作者：
WILLETT, WC
影响因子：
8.8
作者：
Matthews CE;Shu XO;Jin F;Dai Q;Hebert JR;Ruan ZX;Gao YT;Zheng W
通讯作者：
Zheng W
影响因子：
8.8
作者：
Magnusson, CMK;Roddam, AW;Beral, V
通讯作者：
Beral, V