Lifetime physical activity and breast cancer risk in the Shanghai Breast Cancer Study.
Lifetime physical activity and breast cancer risk in the Shanghai Breast Cancer Study.
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DOI：
10.1054/bjoc.2000.1671
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发表时间：
2001-04-06
影响因子：
8.8
通讯作者：
Zheng W
中科院分区：
文献类型：
--
作者：
Matthews CE;Shu XO;Jin F;Dai Q;Hebert JR;Ruan ZX;Gao YT;Zheng W
通过对上海市城区 1459 名新诊断乳腺癌女性和 1556 名年龄匹配的对照者进行面对面访谈，分析了青春期和成年期的总体体力活动以及整个生命周期的活动变化。在青春期（13-19 岁）和成年期（最后 10 岁）评估锻炼和运动、家庭和交通（步行和骑自行车）等身体活动，以及终生职业活动。使用逻辑回归来估计比值比 (OR) 和 95% 置信限 (OR (95% CL))，同时控制混杂因素。仅在青春期锻炼才能降低风险（OR = 0.84 (0.70–1.00)）；仅在成年期进行锻炼（OR = 0.68 (0.53–0.88)），并且在青春期和成年期进一步减少锻炼（OR = 0.47 (0.36–0.62)）。随着参与运动年数的增加，风险逐渐降低（OR 1-5岁= 0.81（0.67-0.94）；OR 6-10岁= 0.74（0.59-0.93）；OR 11-15岁= 0.55（0.38-0.79）；OR 16 + 年= 0.40 (0.27–0.60)；P趋势，< 0.01)。终生职业活动也与风险呈负相关（Ptrend<0.01）。这些发现表明，一生中持续的高活动水平可以降低患乳腺癌的风险。此外，他们建议女性可以通过增加成年后的活动水平来降低风险。 © 2001 癌症研究运动http://www.bjcancer.com
Overall physical activity in adolescence and adulthood, and changes in activity over the lifespan were analysed by in-person interviews among 1459 women newly diagnosed with breast cancer and 1556 age-matched controls in urban Shanghai. Physical activity from exercise and sports, household, and transportation (walking and cycling) was assessed in adolescence (13–19 y) and adulthood (last 10 y), as was lifetime occupational activity. Logistic regression was used to estimate odds ratios (OR) and 95% confidence limits (OR (95% CL)) while controlling for confounders. Risk was reduced for exercise only in adolescence (OR = 0.84 (0.70–1.00)); exercise only in adulthood (OR = 0.68 (0.53–0.88)), and was further reduced for exercise in both adolescence and adulthood (OR = 0.47 (0.36–0.62)). Graded reductions in risk were noted with increasing years of exercise participation (OR 1–5 yrs= 0.81 (0.67–0.94); OR 6–10 yrs= 0.74 (0.59–0.93); OR 11–15 yrs= 0.55 (0.38–0.79); OR 16 + yrs= 0.40 (0.27–0.60);Ptrend,< 0.01). Lifetime occupational activity also was inversely related to risk (Ptrend< 0.01). These findings demonstrate that consistently high activity levels throughout life reduce breast cancer risk. Furthermore, they suggest that women may reduce their risk by increasing their activity levels in adulthood. © 2001 Cancer Research Campaignhttp://www.bjcancer.com
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影响因子：
8.8
作者：
Frisch, R E;Wyshak, G;Albright, N L;Albright, T E;Schiff, I;Jones, K P;Witschi, J;Shiang, E;Koff, E;Marguglio, M
通讯作者：
Marguglio, M
影响因子：
5
作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
通讯作者：
POWELL, JG
影响因子：
8.8
作者：
Carpenter, CL;Ross, RK;Bernstein, L
通讯作者：
Bernstein, L
影响因子：
6.2
作者：
CUNHA, GR
通讯作者：
CUNHA, GR
影响因子：
120.7
作者：
Mayer-Davis, EJ;D'Agostino, R;Bergman, RN
通讯作者：
Bergman, RN