A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder.
A distinct biomarker of continuous transcutaneous vagus nerve stimulation treatment in major depressive disorder.
复制标题
连续经皮迷走神经刺激治疗重度抑郁症的独特生物标志物
DOI：
10.1016/j.brs.2018.01.006
复制
发表时间：
2018-05
影响因子：
7.7
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Tu Y;Fang J;Cao J;Wang Z;Park J;Jorgenson K;Lang C;Liu J;Zhang G;Zhao Y;Zhu B;Rong P;Kong J
重度抑郁症是全球第四大残疾原因，在全球范围内造成社会经济负担。经皮迷走神经刺激（tVNS）是一种有前途的非侵入性临床设备，可能会降低严重抑郁症的严重程度。然而，持续tVNS的神经机制尚未阐明。我们的目的是探讨持续tVNS治疗期间下丘脑亚区功能连接（FC）的变化对重度抑郁症（MDD）患者的影响，并确定治疗结果的潜在生物标志物。招募41名轻中度MDD患者，并接受真实的或假tVNS治疗4周。我们使用种子到全脑的方法来估计连续tVNS治疗期间下丘脑亚区及其周围控制区的FC变化，并探讨其与治疗4周后临床结局变化的相关性。在完成研究的36名患者中，治疗4周后，与假tVNS组相比，tVNS组的24项汉密尔顿抑郁（HAM-D）评定量表评分显著降低。双侧内侧下丘脑（MH）和头端前扣带皮层（rACC）之间的FC在tVNS中显着降低，但在假tVNS中没有。在tVNS治疗4周后，这种FC的强度与HAM-D的改善显著相关。双侧MH和rACC之间的FC可以作为tVNS状态的潜在生物标志物并预测治疗反应。我们的研究结果提供了深入了解连续tVNS的神经调制机制，并揭示了MDD患者的潜在治疗靶点。
Major depression is the fourth leading cause of disability worldwide and poses a socioeconomic burden worldwide. Transcutaneous vagus nerve stimulation (tVNS) is a promising noninvasive clinical device that may reduce the severity of major depression. However, the neural mechanism underlying continuous tVNS has not yet been elucidated. We aimed to explore the effect of hypothalamic subregion functional connectivity (FC) changes during continuous tVNS treatment on major depressive disorder (MDD) patients and to identify the potential biomarkers for treatment outcomes. Forty-one mild to moderate MDD patients were recruited and received either real or sham tVNS treatment for 4 weeks. We used a seed-to-whole brain approach to estimate the FC changes of hypothalamic subregions and their surrounding control areas during continuous tVNS treatment and explored their association with clinical outcome changes after 4 weeks of treatment. Of the thirty-six patients that completed the study, those in the tVNS group had significantly lower scores on the 24-item Hamilton Depression (HAM-D) Rating Scale compared to the sham tVNS group after 4 weeks of treatment. The FC between the bilateral medial hypothalamus (MH) and rostral anterior cingulate cortex (rACC) was significantly decreased during tVNS but not during sham tVNS. The strength of this FC was significantly correlated with HAM-D improvements after 4 weeks of tVNS. The FC between the bilateral MH and rACC may serve as a potential biomarker for the tVNS state and predict treatment responses. Our results provide insights into the neural modulation mechanisms of continuous tVNS and reveal a potential therapeutic target for MDD patients.
登录
查看更多内容
纵向穿迷走神经刺激治疗抑郁症的早期皮质生物标志物。
DOI：
10.1016/j.nicl.2016.12.016
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Fang J;Egorova N;Rong P;Liu J;Hong Y;Fan Y;Wang X;Wang H;Yu Y;Ma Y;Xu C;Li S;Zhao J;Luo M;Zhu B;Kong J
通讯作者：
Kong J
影响因子：
4.6
作者：
Li Z;Liu M;Lan L;Zeng F;Makris N;Liang Y;Guo T;Wu F;Gao Y;Dong M;Yang J;Li Y;Gong Q;Liang F;Kong J
通讯作者：
Kong J
影响因子：
7.7
作者：
Frangos, Eleni;Ellrich, Jens;Komisaruk, Barry R.
通讯作者：
Komisaruk, Barry R.
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
6.7
作者：
Holthoff, VA;Beuthien-Baumann, B;Herholz, K
通讯作者：
Herholz, K