Metabolic phenotype and adipose tissue inflammation in patients with chronic obstructive pulmonary disease.
Metabolic phenotype and adipose tissue inflammation in patients with chronic obstructive pulmonary disease.
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DOI：
10.1155/2010/173498
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发表时间：
2010
影响因子：
4.6
通讯作者：
Tkacova R
中科院分区：
文献类型：
--
作者：
Skyba P;Ukropec J;Pobeha P;Ukropcova B;Joppa P;Kurdiova T;Stroffekova K;Brusik M;Klimes I;Tkac I;Gasperikova D;Tkacova R
慢性阻塞性肺疾病（COPD）患者代谢紊乱和脂肪组织（AT）炎症之间的潜在联系尚未探讨。我们研究了9名恶病质、12名正常体重、12名超重和11名肥胖COPD患者（年龄62.3 ± 7.2岁）中白细胞介素（IL）-6、肿瘤坏死因子（TNF）-α、CD 68（巨噬细胞表面受体）、半胱氨酸蛋白酶-3和Bax的AT表达及其与代谢表型的关系。随着体重指数的增加，IL-6、TNF-α和CD 68的AT表达增加（分别为P <0.001; P = 0.005; P <0.001），与胰岛素敏感性降低有关（P <0.001）。恶病质和正常体重的患者在AT表达的炎症或促凋亡标记物之间没有差异。脂肪组织CD 68和TNF-α表达预测胰岛素敏感性，与已知混杂因素无关（P = 0.005; P = 0.025; R2 = 0.840）。我们的研究结果表明，肥胖COPD患者的AT炎症与胰岛素抵抗有关。恶病质患者保持胰岛素敏感性，没有AT上调炎症或促凋亡标志物。
Potential links between metabolic derangements and adipose tissue (AT) inflammation in patients with chronic obstructive pulmonary disease (COPD) are unexplored. We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3 ± 7.2 years). With increasing body mass index, increases in AT expressions of IL-6, TNF-α, and CD68 were observed (P < .001; P = .005; P < .001, resp.), in association with reduced insulin sensitivity (P < .001). No differences were observed between cachectic and normal-weight patients in AT expressions of inflammatory or proapoptotic markers. Adipose tissue CD68 and TNF-α expressions predicted insulin sensitivity independently of known confounders (P = .005; P = .025; R 2 = 0.840). Our results suggest that AT inflammation in obese COPD patients relates to insulin resistance. Cachectic patients remain insulin sensitive, with no AT upregulation of inflammatory or proapoptotic markers.
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影响因子：
24.3
作者：
Bruno, A;Chanez, P;Vignola, AM
通讯作者：
Vignola, AM
DOI：
10.1164/ajrccm.164.8.2008109
发表时间：
2001-10-15
影响因子：
24.7
作者：
Eid, AA;Ionescu, AA;Shale, DJ
通讯作者：
Shale, DJ
影响因子：
7.7
作者：
Nieto-Vazquez I;Fernández-Veledo S;de Alvaro C;Lorenzo M
通讯作者：
Lorenzo M
影响因子：
5.8
作者：
Klimcakova, E.;Polak, J.;Stich, V.
通讯作者：
Stich, V.
影响因子：
7.1
作者：
Broekhuizen, R;Grimble, RF;Schols, AM
通讯作者：
Schols, AM