Impulsivity in unaffected adolescent biological relatives of schizophrenia patients.
Impulsivity in unaffected adolescent biological relatives of schizophrenia patients.
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DOI：
10.1016/j.jpsychires.2017.11.008
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Koeppel JA
中科院分区：
文献类型：
--
作者：
Ho BC;Barry AB;Koeppel JA
虽然精神分裂症不是一种典型的冲动控制障碍，但患者报告了更多的冲动行为，有更高的物质使用率，并显示出冲动背后的大脑回路功能障碍。我们调查了精神分裂症患者未受影响的生物亲属的冲动性，以进一步了解青春期精神分裂症风险和冲动控制之间的关系。冲动性（UPPS-P冲动行为量表和延迟折扣）的组间差异进行了测试，在210名青少年对比39个一级和53个二级生物亲属的精神分裂症患者，和118名受试者没有精神分裂症家族史（NSFH）。与NSFH青少年和二级亲属相比，精神分裂症患者的一级亲属具有增加的冲动相关行为（更高的UPPS-P毅力，积极紧迫感和预谋子量表评分）和更大的即时奖励偏好（较小的AUC和较大的折扣常数）。二级亲属没有显着差异从NSFH青少年的自我报告冲动行为或冲动决策的措施。即使仔细考虑了潜在的混杂因素，这些组间差异仍然存在。冲动性与精神分裂症风险相关，其严重程度随着与精神分裂症先证者家族关系的增加而增加。需要更多的研究来了解冲动在青春期调解精神分裂症易感性中的作用。
Although schizophrenia is not a prototypic impulse-control disorder, patients report more impulsive behaviors, have higher rates of substance use, and show dysfunction in brain circuits that underlie impulsivity. We investigate impulsivity in unaffected biological relatives of schizophrenia patients to further understand the relationships between schizophrenia risk and impulse control during adolescence. Group differences in impulsivity (UPPS-P Impulsive Behavior Scale and delay discounting) were tested in 210 adolescents contrasting 39 first- and 53 second-degree biological relatives of schizophrenia patients, and 118 subjects with no schizophrenia family history (NSFH). Compared to NSFH adolescents and to second-degree relatives, first-degree relatives of schizophrenia patients had increased impulsivity-related behaviors (higher UPPS-P Perseverance, Positive Urgency and Premeditation subscale scores) and greater preference for immediate rewards (smaller AUC and larger discounting constant). Second-degree relatives did not differ significantly from NSFH adolescents on self-report impulsive behaviors or on measures of impulsive decision-making. These group differences remained even after careful consideration of potential confounding factors. Impulsivity is associated with schizophrenia risk, and its severity increases with greater familial relatedness to the schizophrenia proband. Additional studies are needed to understand the role impulsivity may play in mediating schizophrenia susceptibility during adolescence.
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