Adolescent engagement in dangerous behaviors is associated with increased white matter maturity of frontal cortex.
Adolescent engagement in dangerous behaviors is associated with increased white matter maturity of frontal cortex.
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DOI：
10.1371/journal.pone.0006773
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发表时间：
2009-08-26
期刊：
影响因子：
3.7
通讯作者：
Capra CM
中科院分区：
文献类型：
--
作者：
Berns GS;Moore S;Capra CM
大脑中白色物质的髓鞘形成持续整个青春期和成年早期。这种皮质的不成熟被认为是青春期危险和冲动行为的潜在原因。我们在一组年龄在12-18岁（N = 91）的健康青少年中验证了这一假设，他们接受了弥散张量成像（DTI）来描绘皮质白色物质束。 作为衡量现实世界风险的一项指标，参与者完成了青少年风险问卷（ARQ），该问卷衡量了参与危险活动的程度。在调整了DTI和ARQ的年龄相关变化后，发现危险行为的参与与各向异性分数呈正相关，与额叶白色物质束的横向扩散率呈负相关，表明髓鞘形成和/或纤维密度增加（年龄14-18岁，N = 60）。 相关性的方向表明，从事危险活动的青少年的大脑皮层并不成熟，他们的额叶白色物质束在形式上比保守的同龄人更成熟。
Myelination of white matter in the brain continues throughout adolescence and early adulthood. This cortical immaturity has been suggested as a potential cause of dangerous and impulsive behaviors in adolescence. We tested this hypothesis in a group of healthy adolescents, age 12–18 (N = 91), who underwent diffusion tensor imaging (DTI) to delineate cortical white matter tracts. As a measure of real-world risk taking, participants completed the Adolescent Risk Questionnaire (ARQ) which measures engagement in dangerous activities. After adjusting for age-related changes in both DTI and ARQ, engagement in dangerous behaviors was found to be positively correlated with fractional anisotropy and negatively correlated with transverse diffusivity in frontal white matter tracts, indicative of increased myelination and/or density of fibers (ages 14–18, N = 60). The direction of correlation suggests that rather than having immature cortices, adolescents who engage in dangerous activities have frontal white matter tracts that are more adult in form than their more conservative peers.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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发表时间：
2009-05-01
影响因子：
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作者：
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影响因子：
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作者：
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