Electrophysiological correlates of emotional responding in schizophrenia.
Electrophysiological correlates of emotional responding in schizophrenia.
复制标题
DOI：
10.1037/a0017510
复制
发表时间：
2010-02
影响因子：
4.6
通讯作者：
Green, Michael F.
中科院分区：
文献类型：
--
作者：
Horan, William P.;Wynn, Jonathan K.;Kring, Ann M.;Simons, Robert F.;Green, Michael F.
精神分裂症患者在受到唤起性刺激时始终报告正常水平的愉快情绪，这表明完整的圆满快乐。然而，人们对精神分裂症的神经相关性和情绪的时间进程知之甚少。这项研究使用了经过充分验证的情感图片观看任务，该任务引发了从早期到后期处理阶段（即 P1、P2、P3 和晚期正电位 (LPP)）的事件相关电位 (ERP) 的特征模式。 38 名病情稳定的精神分裂症门诊患者和 36 名健康对照者在记录 ERP 的同时观看了标准化的愉快、不愉快和神经图像，随后评估了他们对刺激的情绪反应。患者和对照者对图片的效价评级以及初始 ERP 成分（P1、P2 和 P3）的反应相似。然而，在后期的 LPP 部分（500 – 1000 毫秒），患者表现出愉快刺激与中性刺激之间的电生理辨别力减弱。这种模式表明患者表现出正常的自我报告情绪体验以及完整的情绪刺激的初始感觉处理和资源分配。然而，它们显示出与情绪刺激的持续注意力处理相关的后续部分的破坏。
People with schizophrenia consistently report normal levels of pleasant emotion when exposed to evocative stimuli, suggesting intact consummatory pleasure. However, little is known about the neural correlates and time course of emotion in schizophrenia. This study used a well-validated affective picture viewing task that elicits a characteristic pattern of Event Related Potentials (ERP) from early to later processing stages (i.e., P1, P2, P3, and Late Positive Potentials (LPP)). Thirty eight stabilized schizophrenia outpatients and 36 healthy controls viewed standardized pleasant, unpleasant, and neural pictures while ERPs were recorded, and subsequently rated their emotional responses to the stimuli. Patients and controls responded to the pictures similarly in terms of their valence ratings, as well as the initial ERP components (P1, P2, and P3). However, at the later LPP component (500 – 1000 ms), patients displayed diminished electrophysiological discrimination between pleasant versus neutral stimuli. This pattern suggests that patients demonstrate normal self-reported emotional experience and intact initial sensory processing of and resource allocation to emotional stimuli. However, they show a disruption in a later component associated with sustained attentional processing of emotional stimuli.
登录
查看更多内容
影响因子：
4.6
作者：
BERENBAUM, H;OLTMANNS, TF
通讯作者：
OLTMANNS, TF
影响因子：
5.7
作者：
Cunningham, WA;Espinet, SD;Zelazo, PD
通讯作者：
Zelazo, PD
影响因子：
3.3
作者：
Gard, David E.;Gard, Marja Germans;John, Oliver P.
通讯作者：
John, Oliver P.
影响因子：
2.6
作者：
Cuthbert, BN;Schupp, HT;Lang, PJ
通讯作者：
Lang, PJ
影响因子：
7.6
作者：
Fredrickson, Barbara L.;Cohn, Michael A.;Coffey, Kimberly A.;Pek, Jolynn;Finkel, Sandra M.
通讯作者：
Finkel, Sandra M.