Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.
Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.
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DOI：
10.1001/archneurol.2011.670
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发表时间：
2012-05
影响因子：
--
通讯作者：
Schaefer, Ernst J.
中科院分区：
文献类型：
--
作者：
van Himbergen, Thomas M.;Beiser, Alexa S.;Ai, Masumi;Seshadri, Sudha;Otokozawa, Seiko;Au, Rhoda;Thongtang, Nuntakorn;Wolf, Philip A.;Schaefer, Ernst J.
研究葡萄糖稳态生物标志物（脂联素、葡萄糖、糖化白蛋白和胰岛素水平）和炎症（高敏C反应蛋白和脂蛋白相关磷脂酶A2水平）对阿尔茨海默病（AD）和全因痴呆风险的影响。前瞻性队列研究。无痴呆心脏病研究参与者在第19次两年一次的检查（1985-1988）中测量了这些生物标志物的血清，并前瞻性地随访了AD和全因痴呆的发展。840名（541名女性，中位年龄76岁）受试者参加了研究。我们使用性别合并和性别特异性多变量考克斯比例风险模型，调整了年龄、教育程度、体重指数、近期体重变化、APOE ε4等位基因状态和血浆二十二碳六烯酸水平，以确定这些生物标志物与全因痴呆和AD发生的相关性。在平均13年的随访期内，159人患上了痴呆症（包括125名AD患者）。校正其他危险因素后，只有女性的脂联素水平每增加1个标准差，与全因痴呆（风险比[HR]，1.29; 95%可信区间[CI]，1.00-1.66; P= 0.054）和AD（HR，1.33; 95% CI，1.00-1.76; P= 0.050）的风险增加相关。基线脂联素值高于中位数的女性与脂联素值低于中位数的女性相比，患全因痴呆（HR，1.63; 95%CI，1.03-2.56; P= 0.04）和AD（HR，1.87; 95%CI，1.13-3.10; P= 0.01）的风险更高。在女性中，血浆脂联素水平升高是全因痴呆和AD发展的独立危险因素。
To investigate the contribution of biomarkers of glucose homeostasis (adiponectin, glucose, glycated albumin, and insulin levels) and inflammation (high-sensitivity C-reactive protein and lipoprotein-associated phospholipase A2 levels) to the risk of developing Alzheimer disease (AD) and all-cause dementia. Prospective cohort study. Dementia-free Framingham Heart Study participants had sera measured for these biomarkers at the 19th biennial examination (1985–1988) and were followed up prospectively for the development of AD and all-cause dementia. Eight hundred forty (541 women, median age of 76 years) subjects participated in the study. We used sex-pooled and sex-specific multivariable Cox proportional hazards models adjusted for age, education, body mass index, recent change in weight, APOE ε4 allele status, and plasma docosahexaenoic acid levels to determine association of these biomarkers with the development of all-cause dementia and AD. Over a mean follow-up period of 13 years, 159 persons developed dementia (including 125 with AD). After adjustment for other risk factors, only adiponectin in women was associated with an increased risk of all-cause dementia (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.00–1.66; P=.054) and AD (HR, 1.33; 95% CI, 1.00–1.76; P=.050) per 1-SD increase in adiponectin level. Women with baseline adiponectin values more than the median had a higher risk of all-cause dementia (HR, 1.63; 95% CI, 1.03–2.56; P=.04) and AD (HR, 1.87; 95% CI, 1.13–3.10; P=.01) as compared with those with values less than the median. In women, increased plasma adiponectin levels are an independent risk factor for the development of both all-cause dementia and AD.
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影响因子：
120.7
作者：
Lieb, Wolfgang;Beiser, Alexa S.;Vasan, Ramachandran S.;Tan, Zaldy S.;Au, Rhoda;Harris, Tamara B.;Roubenoff, Ronenn;Auerbach, Sanford;DeCarli, Charles;Wolf, Philip A.;Seshadri, Sudha
通讯作者：
Seshadri, Sudha
肥胖、2 型糖尿病和阿尔茨海默病。
影响因子：
4
作者：
Luchsinger, Jose A.;Gustafson, Deborah R.
通讯作者：
Gustafson, Deborah R.
影响因子：
5
作者：
Laughlin, Gail A.;Barrett-Connor, Elizabeth;Langenberg, Claudia
通讯作者：
Langenberg, Claudia
影响因子：
4.2
作者：
Haan, Mary N.;Aiello, Allison E.;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
7.7
作者：
Hara, K;Boutin, P;Kadowaki, T
通讯作者：
Kadowaki, T