Peptides and peptide hormones for molecular imaging and disease diagnosis.
Peptides and peptide hormones for molecular imaging and disease diagnosis.
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DOI：
10.1021/cr900361p
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发表时间：
2010-05-12
期刊：
影响因子：
62.1
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Lee, Seulki;Xie, Jin;Chen, Xiaoyuan
分子影像技术是现代诊断中不可或缺的工具，因为它们具有高度特异性，可以在生命系统中提供分子水平的生物信息。1，2它们使一些在疾病过程中起关键作用的特定分子事件可视化，并且它们使早期诊断成为可能，以及监测治疗反应。各种成像模式，包括正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）、光学荧光成像、磁共振成像（MRI）、计算机断层扫描和超声成像，都成功地应用于分子成像领域。特异性成像通常由造影剂产生;然而，由于此类试剂的靶向效率低，大多数当前临床成像仍停留在解剖学和宏观功能水平。为了支持体内临床分子成像的未满足的需求，人们对研究高灵敏度和特异性的分子靶向成像探针的设计产生了相当大的兴趣。迄今为止，已经通过组合各种成像部分（即，放射性同位素、荧光团和纳米颗粒）和靶向配体（即，小分子、肽、蛋白质、抗体以及细胞）开发了大量复杂的成像探针。这些努力深刻地影响了成像探头的可用性，并显着提高了成像模式的性能。几篇综述文章讨论了分子成像探针的最新发展和应用，2-7特别是基于肽和肽序列的成像探针的利用。理想的成像探针将对感兴趣的靶具有高亲和力和特异性。然而，要求
Molecular imaging techniques are now indispensable tools in modern diagnostics, because they are highly specific and can provide biological information at the molecular level in living systems. 1, 2 They have enabled visualization of some of the specific molecular events that play key roles in disease processes, and they have enabled earlier diagnosis, as well as monitoring of therapeutic responses. Various imaging modalities, including positron emission tomography (PET), single photon emission computed tomography (SPECT), optical fluorescence imaging, magnetic resonance imaging (MRI), computed tomography, and ultrasound imaging, are all successfully employed in the field of molecular imaging. Specific imaging is generally created by contrast agents; however, most current clinical imaging remains at the anatomical and macrofunctional level, due to the low targeting efficiency of such agents. To support the unmet needs for in ViVo clinical molecular imaging, there has been considerable interest in investigating the design of highly sensitive and specific molecularly targeted imaging probes. To date, a large variety of sophisticated imaging probes have been developed by combining various imaging moieties (ie, radioisotopes, fluorophores, and nanoparticles) and targeting ligands (ie, small molecules, peptides, proteins, antibodies, as well as cells). These efforts have profoundly impacted the availability of imaging probes and significantly improved the performance of imaging modalities. Several review articles have discussed recent developments and applications of molecular imaging probes, 2–7 particularly the utilization of peptide-and peptide hormone-based imaging probes. An ideal imaging probe would have high affinity and specificity for the target of interest. However, requirements
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DOI：
10.2967/jnumed.108.053546
发表时间：
2009-02
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Budde MD;Frank JA
通讯作者：
Frank JA
DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
通讯作者：
Ruoslahti, E
影响因子：
7.4
作者：
BRIGHT, FV
通讯作者：
BRIGHT, FV
影响因子：
46.9
作者：
Becker, A;Hessenius, C;Grötzinger, C
通讯作者：
Grötzinger, C
影响因子：
14.8
作者：
Blum, Galia;von Degenfeld, Georges;Bogyo, Matthew
通讯作者：
Bogyo, Matthew