Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors.
Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors.
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符合条件的免疫功能正常的献血者中没有抗体血清转换的长期HEV携带者
DOI：
10.1038/s41426-018-0125-y
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发表时间：
2018-07-05
影响因子：
13.2
通讯作者：
Xia NS
中科院分区：
文献类型：
--
作者：
Wen GP;Chen CR;Song XY;Tang ZM;Ji WF;Wang SL;Zhang K;Zhang J;Ou SH;Zheng ZZ;Xia NS
戊型肝炎病毒（HEV）正在成为输血安全的潜在威胁。在许多戊型肝炎流行的国家和地区，如中国，献血者没有常规检测戊型肝炎病毒感染。本研究对11747名符合条件的献血员进行了抗-HEV免疫球蛋白M（IgM）/免疫球蛋白G（IgG）和HEV RNA及抗原筛查。对24名HEV抗原和RNA均为阳性的供体进行了≥ 70天的随访，这些供体均未报告临床肝炎或疾病。17名供体提供了至少1份随访样本，包括10名病毒血症和/或抗原血症≥ 70天，3名抗原和RNA阳性>90天。17名献血者中有14名在随访期间没有出现明显的血清学应答。这些结果不同于以前的报告，其中病毒血症持续68天，并引起抗体反应。这些供体显示出不同于戊型肝炎患者的非典型HEV感染进展。这些供体的存在对输血传播筛查提出了挑战。
Hepatitis E virus (HEV) is emerging as a potential threat to the safety of blood transfusions. In many countries and regions endemic for HEV, such as China, blood donors are not routinely tested for HEV infection. In this study, 11747 eligible blood donors were screened for anti-HEV immunoglobulin M (IgM)/immunoglobulin G (IgG) and HEV RNA and antigen in China. Twenty-four donors who were positive for both HEV antigen and RNA were followed for ≥ 70 days, and none of these donors reported clinical hepatitis or illness. At least 1 follow-up sample was provided by 17 donors, including 10 with viremia and/or antigenemia for ≥ 70 days and 3 with antigen and RNA positivity for >90 days. Fourteen of the 17 donors did not present with an obvious serologic response during the follow-up period. These results differed from previous reports, in which viremia lasted for 68 days and elicited an antibody response. These donors showed atypical HEV infection progression that differed from that of hepatitis E patients. The presence of these donors presents a challenge for transfusion transmission screening.
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影响因子：
25.7
作者：
Haim-Boukobza, Stephanie;Ferey, Marie-Pierre;Roque-Afonso, Anne-Marie
通讯作者：
Roque-Afonso, Anne-Marie
影响因子：
1.5
作者：
Boxall, E;Herborn, A;Teo, CG
通讯作者：
Teo, CG
影响因子：
2.5
作者：
Idolo, A.;Serio, F.;De Donno, A.
通讯作者：
De Donno, A.
DOI：
10.1016/j.trstmh.2005.12.005
发表时间：
2006-10-01
影响因子：
2.2
作者：
Myint, Khin Saw Aye;Endy, Timothy P.;Scott, Robert McN.
通讯作者：
Scott, Robert McN.
影响因子：
6.5
作者：
Chapel H;Cunningham-Rundles C
通讯作者：
Cunningham-Rundles C