Fetal growth and the lifetime risk of generalized anxiety disorder.
Fetal growth and the lifetime risk of generalized anxiety disorder.
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DOI：
10.1002/da.20739
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发表时间：
2010-11
影响因子：
7.4
通讯作者：
Gilman, Stephen E.
中科院分区：
文献类型：
--
作者：
Vasiliadis, Helen-Maria;Buka, Stephen L.;Martin, Laurie T.;Gilman, Stephen E.
焦虑症被认为起源于儿童早期，尽管尚未将其作为胎儿生长受损的潜在结果进行研究，而胎儿生长受损与许多精神病理学的发育病因有关。这项研究调查了胎儿生长指标与广泛性焦虑症（GAD）发展之间的关联。对罗德岛州普罗维登斯合作围产期项目现场参与者的 682 名后代的胎儿生长指标，包括出生体重 (BW) 和体重指数 (PI) 进行了评估。参与者以成年人身份接受访谈，并使用诊断访谈时间表评估他们一生的广泛性焦虑症史。我们使用 Cox 回归来估计胎儿生长指标与 GAD 发展之间的关联。 BW 和 PI 最高类别的婴儿与所有其他类别的婴儿之间，一生中发生广泛性焦虑症 (GAD) 的风险有所不同。出生体重低于 3.5 公斤（风险比，HR：2.38；CI=1.25、4.55）、BW z 得分最低的四个五分位数（HR=2.49；CI=1.14、5.45）或 PI 处于最低的四个五分位数（HR=2.33；CI=1.04、5.00）的新生儿，一生中发生 GAD 的风险较高。与之前关于胎儿生长相关的精神结局的研究相比，出生体重和 GAD 之间不存在线性关系。虽然这些结果总体上支持这样的假设，即胎儿健康的营养吸收（如 BW 和 PI 所示）与更好的终生心理健康相关，但仍需要进一步的工作来表征胎儿生长与随后的精神病理学之间关联的性质。
Anxiety disorders are thought to have their origins in early childhood, though they have not yet been studied as a potential outcome of impaired fetal growth, which has been implicated in the developmental etiologies of many psychopathologies. This study investigated the association between indicators of fetal growth and the development of generalized anxiety disorder (GAD). Indicators of fetal growth, including birth weight (BW) and ponderal index (PI), were assessed among 682 offspring of participants in the Providence, RI, site of the Collaborative Perinatal Project. Participants were interviewed as adults, and their lifetime histories of GAD were assessed using the Diagnostic Interview Schedule. We used Cox regression to estimate the association between fetal growth indicators and the development of GAD. The lifetime risk of GAD differed between infants in the highest category of BW and PI and all others. Newborns with birth weights below 3.5 kg (hazard ratio, HR: 2.38; CI=1.25, 4.55), in the lowest four BW z-score quintiles (HR=2.49; CI=1.14, 5.45) or a PI in the lowest four quintiles (HR=2.33; CI=1.04, 5.00) had higher lifetime risks of GAD. In contrast to prior studies on psychiatric outcomes in relation to fetal growth, there was not a linear relationship between birth weight and GAD. While these results generally support the hypothesis that a healthy nutritional fetal uptake, as indicated by BW and PI, is associated with better lifetime mental health, further work is needed to characterize the nature of the association between fetal growth and subsequent psychopathology.
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影响因子：
10.5
作者：
Gale, CR;Martyn, CN
通讯作者：
Martyn, CN
影响因子：
6.9
作者：
Kessler, R. C.;Gruber, M.;Yonkers, K. A.
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影响因子：
17.7
作者：
Brown, AS;van Os, J;Susser, ES
通讯作者：
Susser, ES
DOI：
10.2307/1166136
发表时间：
1994-01-01
影响因子：
9.5
作者：
Kagan, J
通讯作者：
Kagan, J
影响因子：
5.6
作者：
Hardy, JB
通讯作者：
Hardy, JB