The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fish.
The evolution of the vertebrate cerebellum: absence of a proliferative external granule layer in a non-teleost ray-finned fish.
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DOI：
10.1111/ede.12067
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发表时间：
2014-03
影响因子：
2.9
通讯作者：
Wingate RJ
中科院分区：
文献类型：
--
作者：
Butts T;Modrell MS;Baker CV;Wingate RJ
小脑是脊椎动物大脑中形态变化最大的结构之一。为了阐明其进化历史，我们研究了分子解剖和增殖的发育小脑的北美白鲟，Polyodon spathula。缺乏外部增殖小脑层和限制Atonal 1表达的菱形唇和瓣膜原基表明，过境扩增小脑外部germinal层，一个突出的特点，小脑发育，是不存在的白鲟。此外，Sonic hedgehog的表达，其驱动小鼠小脑中的二次增殖，在白鲟小脑中不存在。这些数据与在斑马鱼中观察到的一致，并表明在斑马鱼小脑中观察到的转运扩增要么在鳍鱼谱系中很早就消失了，要么在叶鳍鱼谱系中进化了。我们还建议，Atoh1阳性增殖瓣膜原基可能代表一个synapomorphy（共享派生字符）的射线鳍鱼。白鲟瓣状原基发育的拓扑结构与斑马鱼的显著不同，并与成年小脑的形态相关。因此，在不同脊椎动物类群中增殖颗粒细胞前体的分布可能是小脑形态多样性的决定因素。
The cerebellum represents one of the most morphologically variable structures in the vertebrate brain. To shed light on its evolutionary history, we have examined the molecular anatomy and proliferation of the developing cerebellum of the North American paddlefish, Polyodon spathula. Absence of an external proliferative cerebellar layer and the restriction of Atonal1 expression to the rhombic lip and valvular primordium demonstrate that transit amplification in a cerebellar external germinal layer, a prominent feature of amniote cerebellum development, is absent in paddlefish. Furthermore, expression of Sonic hedgehog, which drives secondary proliferation in the mouse cerebellum, is absent from the paddlefish cerebellum. These data are consistent with what has been observed in zebrafish and suggest that the transit amplification seen in the amniote cerebellum was either lost very early in the ray-finned fish lineage or evolved in the lobe-finned fish lineage. We also suggest that the Atoh1-positive proliferative valvular primordium may represent a synapomorphy (shared derived character) of ray-finned fishes. The topology of valvular primordium development in paddlefish differs significantly from that of zebrafish and correlates with the adult cerebellar form. The distribution of proliferative granule cell precursors in different vertebrate taxa is thus the likely determining factor in cerebellar morphological diversity.
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影响因子：
2.7
作者：
Kani, Shuichi;Bae, Young-Ki;Hibi, Masahiko
通讯作者：
Hibi, Masahiko
影响因子：
5.3
作者：
Maricich, Stephen M.;Xia, Anping;Zoghbi, Huda Y.
通讯作者：
Zoghbi, Huda Y.
影响因子：
64.8
作者：
BenArie, N;Bellen, HJ;Zoghbi, HY
通讯作者：
Zoghbi, HY
影响因子：
2.5
作者：
Ekström, P;Johnsson, CM;Ohlin, LM
通讯作者：
Ohlin, LM
DOI：
10.1126/science.1181453
发表时间：
2009-12-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Flora A;Klisch TJ;Schuster G;Zoghbi HY
通讯作者：
Zoghbi HY