CD-Based Microfluidics for Primary Care in Extreme Point-of-Care Settings.
CD-Based Microfluidics for Primary Care in Extreme Point-of-Care Settings.
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DOI：
10.3390/mi7020022
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发表时间：
2016-01-29
期刊：
影响因子：
3.4
通讯作者：
Korvink JG
中科院分区：
文献类型：
--
作者：
Smith S;Mager D;Perebikovsky A;Shamloo E;Kinahan D;Mishra R;Torres Delgado SM;Kido H;Saha S;Ducrée J;Madou M;Land K;Korvink JG
我们回顾了离心式微流控技术在资源极度匮乏的环境中应用于就诊诊断的应用。以印度和非洲地区为例，展示了在这些环境中面临的各种挑战。重点介绍了集成设备有效应对护理点挑战的能力的措施，并介绍了通常称为基于CD的微流控技术的离心式技术，认为这些技术是应对这些挑战的一个有前途的平台。我们描述了离心液处理的优点，以及标准CD播放机执行一些常见实验室测试的能力，实现了CD上的综合实验室的作用。重点介绍了在资源极其匮乏的环境中提供护理点的创新离心法，包括传感和检测战略、智能电源和环境控制的仿生灵感。介绍了离心式微流控系统的发展，以及商用和高级原型离心式微流控系统的实例，说明了在护理点部署的成功。一个新出现的离心机系统的紧密配合，以解决资源不足的临床设置的关键测试小组，由医学专家制定，被证明。这强调了离心式微流控技术有潜力有效地应用于极具挑战性的护理地点方案，并在改善发展中国家资源有限环境中的初级保健方面发挥作用。
We review the utility of centrifugal microfluidic technologies applied to point-of-care diagnosis in extremely under-resourced environments. The various challenges faced in these settings are showcased, using areas in India and Africa as examples. Measures for the ability of integrated devices to effectively address point-of-care challenges are highlighted, and centrifugal, often termed CD-based microfluidic technologies, technologies are presented as a promising platform to address these challenges. We describe the advantages of centrifugal liquid handling, as well as the ability of a standard CD player to perform a number of common laboratory tests, fulfilling the role of an integrated lab-on-a-CD. Innovative centrifugal approaches for point-of-care in extremely resource-poor settings are highlighted, including sensing and detection strategies, smart power sources and biomimetic inspiration for environmental control. The evolution of centrifugal microfluidics, along with examples of commercial and advanced prototype centrifugal microfluidic systems, is presented, illustrating the success of deployment at the point-of-care. A close fit of emerging centrifugal systems to address a critical panel of tests for under-resourced clinic settings, formulated by medical experts, is demonstrated. This emphasizes the potential of centrifugal microfluidic technologies to be applied effectively to extremely challenging point-of-care scenarios and in playing a role in improving primary care in resource-limited settings across the developing world.
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影响因子：
3.7
作者：
Al-Faqheri W;Ibrahim F;Thio TH;Moebius J;Joseph K;Arof H;Madou M
通讯作者：
Madou M
影响因子：
2.8
作者：
Chen, Jerry M.;Huang, Po-Chun;Lin, Mou-Gee
通讯作者：
Lin, Mou-Gee
影响因子：
6.1
作者：
Brenner, T;Glatzel, T;Ducrée, J
通讯作者：
Ducrée, J
影响因子：
6.1
作者：
Aeinehvand MM;Ibrahim F;Harun SW;Al-Faqheri W;Thio TH;Kazemzadeh A;Madou M
通讯作者：
Madou M
影响因子：
7.4
作者：
Christodouleas, Dionysios C.;Nemiroski, Alex;Whitesides, George M.
通讯作者：
Whitesides, George M.