Histone acetyltransferases in plant development and plasticity.
Histone acetyltransferases in plant development and plasticity.
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DOI：
10.2174/138920291501140306112742
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发表时间：
2014-02
期刊：
影响因子：
2.6
通讯作者：
Iantcheva A
中科院分区：
文献类型：
--
作者：
Boycheva I;Vassileva V;Iantcheva A
在真核生物中，转录调控是由动态和可逆的染色质修饰决定的，如乙酰化、甲基化、磷酸化、泛素化、糖基化，这些修饰对DNA复制、DNA修复、重组和基因转录过程至关重要。组蛋白乙酰化的可逆和快速变化诱导基因表达的全基因组和特异性改变，并在染色质修饰中发挥关键作用。由于它们的固着生活方式，植物无法逃避环境胁迫，因此进化出许多适应性以在胁迫环境中生存。染色质修饰在调节植物基因表达的非生物和生物胁迫下发挥重要作用。植物也能够对影响基因组完整性的信号做出反应。所有这些因素都与通过组蛋白乙酰化修饰的基因表达水平的变化有关。本文综述了组蛋白乙酰转移酶基因的主要类型、结构、功能、与其他基因的相互作用、参与植物对环境刺激的反应以及在细胞周期进程中的作用。我们还汇集了最新的研究结果，组蛋白乙酰转移酶HAC1的模式豆科植物蒺藜苜蓿和百脉根。
In eukaryotes, transcriptional regulation is determined by dynamic and reversible chromatin modifications, such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, that are essential for the processes of DNA replication, DNA-repair, recombination and gene transcription. The reversible and rapid changes in histone acetylation induce genome-wide and specific alterations in gene expression and play a key role in chromatin modification. Because of their sessile lifestyle, plants cannot escape environmental stress, and hence have evolved a number of adaptations to survive in stress surroundings. Chromatin modifications play a major role in regulating plant gene expression following abiotic and biotic stress. Plants are also able to respond to signals that affect the maintaince of genome integrity. All these factors are associated with changes in gene expression levels through modification of histone acetylation. This review focuses on the major types of genes encoding for histone acetyltransferases, their structure, function, interaction with other genes, and participation in plant responses to environmental stimuli, as well as their role in cell cycle progression. We also bring together the most recent findings on the study of the histone acetyltransferase HAC1 in the model legumes Medicago truncatula and Lotus japonicus.
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