Association between TFEB gene polymorphism, gene-environment interaction, and fatty liver disease: A case-control study in China.
Association between TFEB gene polymorphism, gene-environment interaction, and fatty liver disease: A case-control study in China.
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TFEB 基因多态性、基因-环境相互作用与脂肪肝的关联：中国的病例对照研究。
DOI：
10.1177/00368504211043766
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发表时间：
2021-07
期刊：
影响因子：
2.1
通讯作者：
中科院分区：
文献类型：
--
作者：
脂肪肝（FLD）是一个严重的公共卫生问题，正在迅速增加。有证据表明转录因子EB （TFEB）基因可能参与了FLD的病理生理过程；然而，TEFB多态性是否与FLD相关尚不清楚。探讨TFEB多态性、基因-环境相互作用与FLD的关系，为阐明FLD的遗传因素提供流行病学依据。本研究为病例对照研究。采用Sequenom MassARRAY进行基因分型。采用逻辑回归分析TFEB多态性与FLD的相关性，并采用乘法和加性相互作用模型评价FLD的基因-环境相互作用。(1)病例组和对照组TFEB各单核苷酸多态性和单倍型的等位基因和基因型分布均匀；没有观察到统计学上的显著差异。(2) Logistic回归分析显示TFEB多态性与FLD无显著相关。(3)在乘法交互模型中，rs1015149、rs1062966、rs11754668和rs2273068与吸烟量的交互作用显著。Rs1062966和rs11754668也分别与体重指数和酒精摄入量有相当大的交互作用。然而，没有观察到显著的加性相互作用。TFEB多态性与FLD易感性无直接关系，但可通过基因-环境相互作用改变风险。
Fatty liver disease (FLD) is a serious public health problem that is rapidly increasing. Evidence indicates that the transcription factor EB (TFEB) gene may be involved in the pathophysiology of FLD; however, whether TEFB polymorphism has an association with FLD remains unclear. To explore the association among TFEB polymorphism, gene–environment interaction, and FLD and provide epidemiological evidence for clarifying the genetic factors of FLD. This study is a case–control study. Sequenom MassARRAY was applied in genotyping. Logical regression was used to analyze the association between TFEB polymorphism and FLD, and the gene–environment interaction in FLD was evaluated by multiplication and additive interaction models. (1) The alleles and genotypes of each single nucleotide polymorphism and haplotypes of TFEB in the case and control groups were evenly distributed; no statistically substantial difference was observed. (2) Logistic regression analysis indicated that TFEB polymorphism is not remarkably associated with FLD. (3) In the multiplicative interaction model, rs1015149, rs1062966, rs11754668 and rs2273068 had remarkable interaction with the amount of cigarette smoking. Rs1062966 and rs11754668 also had a considerable interaction body mass index and alcohol intake, respectively. However, no remarkable additive interaction was observed. TFEB polymorphism is not directly associated with FLD susceptibility, but the risk can be changed through gene–environment interaction.
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