Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men.
Independent and joint effects of moderate alcohol consumption and smoking on the risks of non-alcoholic fatty liver disease in elderly Chinese men.
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适量饮酒和吸烟对中国老年男性非酒精性脂肪肝风险的独立和联合影响
DOI：
10.1371/journal.pone.0181497
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Yao P
中科院分区：
文献类型：
--
作者：
Liu P;Xu Y;Tang Y;Du M;Yu X;Sun J;Xiao L;He M;Wei S;Yuan J;Wang Y;Liang Y;Wu T;Miao X;Yao P
背景吸烟和适度饮酒是否与非酒精性脂肪性肝病(NAFLD)有关，目前还没有完全的描述。本研究调查了吸烟和适度饮酒对中国男性NAFLD的单独和联合影响。方法采用DFTJ队列研究中的横断面分析方法，对9432名不含过量饮酒(210g/周)的老年男性进行调查。脂肪肝的诊断采用标准化超声检查。采用多因素Logistic回归分析饮酒和吸烟对NAFLD患病率的优势比(OR)。结果当前吸烟者(≥40)和饮酒者(80~210g/周或饮酒年限≥35年)非酒精性脂肪肝的患病率显著高于非吸烟者和非饮酒者。当前吸烟(一年≥40)和饮酒(80~210克/周)与非酒精性脂肪肝的高风险相关(OR1.85；95%可信区间1.28~2.68；P<；0.01)。在≥为40和饮酒持续时间≥为35年的参与者中也发现了类似的联合效应(OR1.72；95%可信区间1.26-2.34；P<；0.01)。此外，在NAFLD中观察到当前吸烟和适度饮酒之间存在交互作用。结论在中国老年男性中，吸烟和适度饮酒对NAFLD的患病率有明显的联合作用和交互作用，但两者均与NAFLD的患病率显著独立相关。这些发现突出了避免吸烟和酒精对预防非酒精性脂肪肝的特别重要意义。
Background Whether cigarette smoking and moderate drinking are associated with non-alcoholic fatty liver disease (NAFLD)has not been fully described. This study investigated the separate and joint effects of smoking and moderate drinking on Chinese men with NAFLD. Methods Across-sectional assay from DFTJ Cohort study was performed with a size of 9432 elderly Chinese men excluding excessive alcohol consumption (<210g/week). Fatty liver was diagnosed by standardized ultrasonographic inspection. The odds ratio (OR) of alcohol consumption and smoking for the prevalence of NAFLD were analyzed using multiple logistic regression with multiple adjustments. Results The prevalence of NAFLD in current smokers (pack-year≥40) and drinkers (80~210g/week or drinking duration≥35years) was significantly higher than that in non-smokers and non-drinkers, respectively. The combination of current smoking (pack-year≥40) and drinking (80~210g/week) was associated with the highest risk of NAFLD (OR 1.85; 95% confidence interval [CI] 1.28–2.68;P<0.01). The similar combined effect was found in participants with pack-year≥40 and drinking duration≥35 years (OR 1.72; 95% CI 1.26–2.34;P<0.01). Moreover, an interaction was observed between current smoking and moderate drinking in NAFLD. Conclusions In elderly Chinese men, cigarette smoking and moderate alcohol consumption exerts an evident joint effect and interaction on the prevalence of NAFLD, although both are significantly and independently associated with NAFLD prevalence. Such findings highlight particular significance of avoidance of cigarette and alcohol on NAFLD prevention.
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DOI：
10.1136/bmj.h4238
发表时间：
2015-08-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Cao Y;Willett WC;Rimm EB;Stampfer MJ;Giovannucci EL
通讯作者：
Giovannucci EL
影响因子：
7.6
作者：
Moriya, A.;Iwasaki, Y.;Yamamoto, K.
通讯作者：
Yamamoto, K.
影响因子：
9.8
作者：
Gunji, Toshiaki;Matsuhashi, Nobuyuki;Urabe, Akio
通讯作者：
Urabe, Akio
影响因子：
13.6
作者：
Andersson, T;Alfredsson, L;Ahlbom, A
通讯作者：
Ahlbom, A
影响因子：
25.7
作者：
Moriya, Akio;Iwasaki, Yoshiaki;Yamamoto, Kazuhide
通讯作者：
Yamamoto, Kazuhide