A Systematic Thermal Analysis for Accurately Predicting the Extrusion Printability of Alginate-Gelatin-Based Hydrogel Bioinks.
A Systematic Thermal Analysis for Accurately Predicting the Extrusion Printability of Alginate-Gelatin-Based Hydrogel Bioinks.
复制标题
用于准确预测海藻酸盐-明胶水凝胶生物墨水的挤出印刷适性的系统热分析
DOI：
10.18063/ijb.v7i3.394
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发表时间：
2021
影响因子：
8.4
通讯作者：
Bai D
中科院分区：
文献类型：
--
作者：
Li Q;Zhang B;Xue Q;Zhao C;Luo Y;Zhou H;Ma L;Yang H;Bai D
三维（3D）生物打印在解决全球器官短缺问题方面具有巨大的潜力。挤出打印是一种多功能的生物3D打印技术，但其低精度目前限制了解决方案。这种精度的缺乏很大程度上归因于生物墨水复杂的热和动态特性，这使得很难对打印结果进行准确的估计。为了解决这个问题，有必要了解印刷温度和材料印刷适性之间的关系。本文提出了一个定量的热模型，结合系统的打印温度（注射器，环境和生物墨水），以方便准确估计打印结果。建立了一个物理模型，揭示了温度、压力和速度之间的关系，以指导海藻酸钠-明胶复合水凝胶（一种流行的生物墨水）的打印，以优化其挤出打印性能。该模型考虑了生物墨水模具挤压后的膨胀现象。一系列的挤压实验证实，与传统模型相比，所提出的模型提供了更好的打印结果估计。采用32号和23号两种喷嘴分别调节挤出物的温度、压力和速度，打印出线宽步长为50mm的几组线条。该研究证实了基于所提出的优化方法建立合理、准确的开环线宽控制的潜力，从而进一步扩大挤压生物打印的应用范围。
Three-dimensional (3D) bioprinting has significant potential for addressing the global problem of organ shortages. Extrusion printing is a versatile 3D bioprinting technique, but its low accuracy currently limits the solution. This lack of precision is attributed largely to the complex thermal and dynamic properties of bioinks and makes it difficult to provide accurate estimations of the printed results. It is necessary to understand the relationship between printing temperature and materials’ printability to address this issue. This paper proposes a quantitative thermal model incorporating a system’s printing temperatures (syringe, ambient, and bioink) to facilitate accurate estimations of the printing outcomes. A physical model was established to reveal the relationship between temperature, pressure, and velocity in guiding the printing of sodium alginate–gelatin composite hydrogel (a popular bioink) to optimize its extrusion-based printability. The model considered the phenomenon of bioink die swells after extrusion. A series of extrusion experiments confirmed that the proposed model offers enhanced printing outcome estimations compared with conventional models. Two types of nozzles (32- and 23-gauge) were used to print several sets of lines with a linewidth step of 50 mm by regulating the extrudate’s temperature, pressure, and velocity separately. The study confirmed the potential for establishing a reasonable, accurate open-loop linewidth control based on the proposed optimization method to expand the application of extrusion-based bioprinting further.
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影响因子：
16.6
作者：
Kong, Bin;Chen, Yun;Mi, Shengli
通讯作者：
Mi, Shengli
影响因子：
9
作者：
Gao T;Gillispie GJ;Copus JS;Pr AK;Seol YJ;Atala A;Yoo JJ;Lee SJ
通讯作者：
Lee SJ
DOI：
10.1002/adma.201604630
发表时间：
2017-01
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Liu W;Zhang YS;Heinrich MA;De Ferrari F;Jang HL;Bakht SM;Alvarez MM;Yang J;Li YC;Trujillo-de Santiago G;Miri AK;Zhu K;Khoshakhlagh P;Prakash G;Cheng H;Guan X;Zhong Z;Ju J;Zhu GH;Jin X;Shin SR;Dokmeci MR;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
8.4
作者：
Kolan, Krishna C. R.;Semon, Julie A.;Leu, Ming C.
通讯作者：
Leu, Ming C.
影响因子：
46.9
作者：
Kang, Hyun-Wook;Lee, Sang Jin;Atala, Anthony
通讯作者：
Atala, Anthony