Decreased somatosensory activity to non-threatening touch in combat veterans with posttraumatic stress disorder.
Decreased somatosensory activity to non-threatening touch in combat veterans with posttraumatic stress disorder.
复制标题
DOI：
10.1016/j.pscychresns.2015.06.012
复制
发表时间：
2015-08-30
影响因子：
11.3
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Badura-Brack AS;Becker KM;McDermott TJ;Ryan TJ;Becker MM;Hearley AR;Heinrichs-Graham E;Wilson TW
创伤后应激障碍（PTSD）是一种严重的精神疾病，在战斗退伍军人中普遍存在。以往的神经影像学研究表明，PTSD患者表现出对非威胁性视觉和听觉刺激的异常反应，但没有检查躯体感觉处理。30名男性退伍军人，16名患有PTSD，14名没有，在306传感器脑磁图（MEG）记录期间完成了触觉刺激任务。显着的振荡神经反应，使用波束形成方法成像。参与者还完成了创伤后应激障碍，战斗暴露和抑郁症的临床评估。我们发现，与战斗控制相比，患有PTSD的退伍军人在早期（0至125毫秒）触觉处理过程中表现出显着减少的活动。具体来说，与没有创伤后应激障碍的老兵相比，患有创伤后应激障碍的老兵在对非威胁性触觉刺激的反应中，左中央后回、左上级顶叶区和右前额叶皮层的活动较弱。这些大脑区域的活动程度与症状的严重程度呈负相关，这表明那些患有最严重的PTSD的人有最异常的神经反应。我们的研究结果与PTSD中知觉处理的资源分配观点一致，PTSD将注意力从非威胁性的感官信息上转移开。
Posttraumatic stress disorder (PTSD) is a severe psychiatric disorder prevalent in combat veterans. Previous neuroimaging studies have demonstrated that patients with PTSD exhibit abnormal responses to non-threatening visual and auditory stimuli, but have not examined somatosensory processing. Thirty male combat veterans, 16 with PTSD and 14 without, completed a tactile stimulation task during a 306-sensor magnetoencephalography (MEG) recording. Significant oscillatory neural responses were imaged using a beamforming approach. Participants also completed clinical assessments of PTSD, combat exposure, and depression. We found that veterans with PTSD exhibited significantly reduced activity during early (0 to 125 ms) tactile processing compared with combat controls. Specifically, veterans with PTSD had weaker activity in the left postcentral gyrus, left superior parietal area, and right prefrontal cortex in response to nonthreatening tactile stimulation relative to veterans without PTSD. The magnitude of activity in these brain regions was inversely correlated with symptom severity, indicating that those with the most severe PTSD had the most abnormal neural responses. Our findings are consistent with a resource allocation view of perceptual processing in PTSD, which directs attention away from nonthreatening sensory information.
登录
查看更多内容
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
4.3
作者：
Eckart, Cindy;Stoppel, Christian;Kolassa, Iris-Tatjana
通讯作者：
Kolassa, Iris-Tatjana
影响因子：
4.8
作者：
Gjini, Klevest;Boutros, Nash N.;Tancer, Manuel E.
通讯作者：
Tancer, Manuel E.
影响因子：
10.3
作者：
Felmingham, Kim L.;Rennie, Chris;Bryant, Richard A.
通讯作者：
Bryant, Richard A.
创伤后应激障碍中颞上回的听觉M50感觉门控和皮质厚度的横向异常：初步结果。
影响因子：
2.3
作者：
Hunter, Michael;Villarreal, Gerardo;McHaffie, Greg R.;Jimenez, Billy;Smith, Ashley K.;Calais, Lawrence A.;Hanlon, Faith;Thoma, Robert J.;Canive, Jose M.
通讯作者：
Canive, Jose M.