Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary results.
Lateralized abnormalities in auditory M50 sensory gating and cortical thickness of the superior temporal gyrus in post-traumatic stress disorder: preliminary results.
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创伤后应激障碍中颞上回的听觉M50感觉门控和皮质厚度的横向异常：初步结果。
DOI：
10.1016/j.pscychresns.2010.09.012
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发表时间：
2011-02-28
影响因子：
2.3
通讯作者：
Canive, Jose M.
中科院分区：
文献类型：
--
作者：
Hunter, Michael;Villarreal, Gerardo;McHaffie, Greg R.;Jimenez, Billy;Smith, Ashley K.;Calais, Lawrence A.;Hanlon, Faith;Thoma, Robert J.;Canive, Jose M.
创伤后应激障碍（PTSD）的特征是由暴露于创伤事件引起的独特症状。这些症状包括持续重新体验事件，避免与事件相关的刺激，一般反应麻木和觉醒增加（DSM-IV-TR）。创伤后应激障碍的神经生理学研究已经显示了信息处理的基本机制的损伤（综述参见Karl等人，2006 a），特别是在抑制网络中（Paige et al.，1990; Gillette等人，1997; Neylan等人，1999; Skinner等人，1999; Mennings等人，2008).听觉诱发电位（EP）P50的感觉门控已经被用作感觉过滤的神经生理学测量，感觉过滤在处理流中如此早地发生，以至于它已经被描述为前注意（Adler等人，1982年）。在健康的参与者中，当两个听觉咔嗒声非常接近（500 ms）时，对第二次咔嗒声（S2）的响应幅度明显小于对第一次咔嗒声（S1）的响应幅度。涉及S2抑制的过程称为感觉门控，其通常表示为S2与S1的比率（Adler等人，1982年）。
Post-traumatic stress disorder (PTSD) is characterized by unique symptoms resulting from the exposure of a traumatic event. These symptoms include persistent re-experiencing of the event, avoidance of stimuli associated with the event, numbing of general responsiveness, and increased arousal (DSM-IV-TR). Neurophysiological research in PTSD has shown impairments in essential mechanisms underlying information processing (for review see Karl et al., 2006a), particularly within the inhibitory network (Paige et al., 1990; Gillette et al., 1997; Neylan et al., 1999; Skinner et al., 1999; Mennings et al., 2008).Sensory gating of the auditory evoked potential (EP) P50 has been used as a neurophysiological measure of sensory filtering that occurs so early in the processing stream that it has been described as pre-attentive (Adler et al., 1982). In healthy participants, when two auditory clicks are presented in close proximity (500 ms), the response amplitude to the secondclick (S2) is significantly smaller in relation to the response amplitude to the firstclick (S1). The process involved in the inhibition of S2 is referred to as sensory gating, which is usually expressed as the ratio of S2 to S1 (Adler et al., 1982).
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