Metaproteomic analysis of human gut microbiome in digestive and metabolic diseases.

Metaproteomic analysis of human gut microbiome in digestive and metabolic diseases.
复制标题

DOI:
10.1016/bs.acc.2019.12.002
复制
发表时间:
2020
影响因子:
--
通讯作者:
Chen, Ru
Chen, Ru
中科院分区:
医学2区
文献类型:
--
作者:
Pan, Sheng;Chen, Ru

文献摘要

参考文献

被引文献

相似文献

作为蛋白质组学的一个分支,元蛋白质组学已迅速成为在功能水平上对微生物组系统进行全球表征的关键工具。它已越来越多地应用于研究人类消化和代谢疾病,并提供信息丰富的数据,以确定与健康或疾病状态相关的人类肠道微生物组的生态失调,以阐明宿主-微生物群相互作用的分子事件。虽然仍然存在重大的技术挑战,但这一新兴技术已被证明可以为询问人类肠道微生物组的功能变化提供重要信息,作为宏基因组学和元转录组学的补充。本章概述了总体元蛋白质组学的工作流程及其在研究与消化和代谢疾病相关的人类肠道微生物组中的最新应用。
Metaproteomics, as a subfield of proteomics, has quickly emerged as a pivotal tool for global characterization of a microbiome system at a functional level. It has been increasingly applied in studying human digestive and metabolic diseases, and provides information-rich data to identify the dysbiosis of human gut microbiome related to healthy or disease states to elucidate the molecular events underlying host-microbiota interplays. While significant technical challenges still exist, this emerging technology has been demonstrated to provide essential information in interrogating functional changes in the human gut microbiome, complementary to metagenomics and metatranscriptomics. This chapter overviews the overall metaproteomic work flow and its recent applications in studying human gut microbiome relevant to digestive and metabolic diseases.
DOI: 10.1128/mbio.01343-17
发表时间: 2017-10-17
期刊: mBio
影响因子: 6.4
作者:
Maier TV;Lucio M;Lee LH;VerBerkmoes NC;Brislawn CJ;Bernhardt J;Lamendella R;McDermott JE;Bergeron N;Heinzmann SS;Morton JT;González A;Ackermann G;Knight R;Riedel K;Krauss RM;Schmitt-Kopplin P;Jansson JK
通讯作者: Jansson JK
DOI: 10.1371/journal.pone.0049138
发表时间: 2012
期刊: PloS one
影响因子: 3.7
作者:
Erickson AR;Cantarel BL;Lamendella R;Darzi Y;Mongodin EF;Pan C;Shah M;Halfvarson J;Tysk C;Henrissat B;Raes J;Verberkmoes NC;Fraser CM;Hettich RL;Jansson JK
通讯作者: Jansson JK
DOI: 10.1021/acs.jproteome.8b00716
发表时间: 2019-02-01
影响因子: 4.4
作者:
Gurdeep Singh, Robbert;Tanca, Alessandro;Mesuere, Bart
通讯作者: Mesuere, Bart
DOI: 10.1016/j.jprot.2019.04.009
发表时间: 2019-06-15
影响因子: 3.3
作者:
Lehmann, T.;Schallert, K.;Heyer, R.
通讯作者: Heyer, R.
元蛋白质组学是健康和疾病中肠道菌群的互补方法。
DOI: 10.3389/fchem.2017.00004
发表时间: 2017
影响因子: 5.5
作者:
Petriz BA;Franco OL
通讯作者: Franco OL