Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis.
Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis.
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DOI：
10.1186/ar3246
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发表时间：
2011-02-14
影响因子：
4.9
通讯作者：
Kaneko K
中科院分区：
文献类型：
--
作者：
Ishijima M;Watari T;Naito K;Kaneko H;Futami I;Yoshimura-Ishida K;Tomonaga A;Yamaguchi H;Yamamoto T;Nagaoka I;Kurosawa H;Poole RA;Kaneko K
我们检验了这样一个假设，即早期放射学定义的膝关节骨关节炎（OA）的发病、疼痛和关节代谢生物标志物的变化之间存在关系。46例患者中，16例采用Kelling-Lawrence（K/L）分级，早期X线检查发现膝关节OA（K/L2）。根据是否存在持续性膝关节疼痛，将这些等级（K/L 1为无OA，K/L 2为早期OA）分为两组。用软骨胶原裂解（sC 2C和uCTX-II）和合成（sCPII）、骨吸收（uNTx）和滑膜炎（透明质酸：sHA）的生物标志物分析血清和尿液。sCPII降低，sC 2C/sCPII、uCTX-II/sCPII和sHA随OA发作而升高（K/L 2 vs K/L 1），与关节疼痛无关。相比之下，sC 2C和uCTX-II在早期OA患者中保持不变。在K/L 1级和2级患者中，sC 2C、sCPII、sHA、uNTX和uCTX-II在膝关节疼痛患者中均显著升高，与级别无关。在K/L 2级受试者中，仅膝关节疼痛受试者的uCTX-II和uCTX-II/sCPII升高。在1级患者中，膝关节疼痛的sC 2C和sCPII均升高。对于其他生物标志物（包括sHA），未观察到此类级别特异性变化。这些结果表明，通过分子生物标志物检测到的软骨基质周转的变化可能反映了软骨结构的早期变化，这些变化直接或间接地导致了膝关节疼痛。K/L 1级膝关节疼痛患者也表现出早期OA的生物标志物特征。
We tested the hypothesis that there exist relationships between the onset of early stage radiographically defined knee osteoarthritis (OA), pain and changes in biomarkers of joint metabolism. Using Kellgren-Lawrence (K/L) grading early radiographic knee OA (K/L 2) was detected in 16 of 46 patients. These grades (K/L 1 is no OA and K/L 2 is early OA) were divided into two groups according to the presence or absence of persistent knee pain. Sera (s) and urines (u) were analysed with biomarkers for cartilage collagen cleavage (sC2C and uCTX-II) and synthesis (sCPII), bone resorption (uNTx) and synovitis (hyaluronic acid: sHA). sCPII decreased and sC2C/sCPII, uCTX-II/sCPII and sHA increased with onset of OA (K/L 2 versus K/L 1) irrespective of joint pain. In contrast, sC2C and uCTX-II remained unchanged in early OA patients. Of the patients with K/L grades 1 and 2 sC2C, sCPII, sHA, uNTX and uCTX-II were all significantly increased in patients with knee pain independent of grade. Among the K/L grade 2 subjects, only uCTX-II and uCTX-II/sCPII were increased in those with knee pain. In grade 1 patients both sC2C and sCPII were increased in those with knee pain. No such grade specific changes were seen for the other biomarkers including sHA. These results suggest that changes in cartilage matrix turnover detected by molecular biomarkers may reflect early changes in cartilage structure that account directly or indirectly for knee pain. Also K/L grade 1 patients with knee pain exhibit biomarker features of early OA.
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影响因子：
--
作者：
Garnero, P;Ayral, X;Delmas, PD
通讯作者：
Delmas, PD
DOI：
10.1016/j.berh.2005.09.001
发表时间：
2006-02-01
影响因子：
5.2
作者：
Kraus, VB
通讯作者：
Kraus, VB
影响因子：
--
作者：
Garnero, P;Peterfy, C;Schoenharting, M
通讯作者：
Schoenharting, M
影响因子：
158.5
作者：
Felson, DT
通讯作者：
Felson, DT
影响因子：
7
作者：
Bay-Jensen, A. -C.;Andersen, T. L.;Delaisse, J. -M.
通讯作者：
Delaisse, J. -M.