Recent advances in graphene-based nanobiosensors for salivary biomarker detection.
Recent advances in graphene-based nanobiosensors for salivary biomarker detection.
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DOI：
10.1016/j.bios.2020.112723
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发表时间：
2021-01-01
影响因子：
12.6
通讯作者：
Yeo WH
中科院分区：
文献类型：
--
作者：
Goldoni R;Farronato M;Connelly ST;Tartaglia GM;Yeo WH
由于材料、化学和电子学的重大发展，生物传感研究正在迅速发展，研究人员努力构建能够以高灵敏度和特异性检测健康监测生物标志物的尖端生物医学设备。利用纳米材料的生物传感器具有检测范围宽、响应时间快、系统小型化、灵敏度高等优点，具有广阔的应用前景。在生物传感器和电子学的最新发展中，石墨烯由于其上级的电学、生物化学和机械性能而迅速普及。对于生物标志物检测，人类唾液提供了多种分析物的容易获取，使其成为用于即时护理（POC）设备的有希望的候选者。在这里，我们报告了一个全面的审查，总结了最新的石墨烯为基础的纳米生物传感器和口腔生物电子唾液生物标志物检测。我们讨论了石墨烯电子器件的结构设计、唾液生物标志物的用例、现有传感器的性能以及在健康监测中的应用的细节。本文还介绍了当前石墨烯生物电子学在材料和系统方面的挑战以及临床POC应用的未来方向。总的来说，本文的主要贡献是对石墨烯生物传感器和口腔电子学及其在人类唾液生物标志物检测中的成功应用进行了广泛的综述。
As biosensing research is rapidly advancing due to significant developments in materials, chemistry, and electronics, researchers strive to build cutting-edge biomedical devices capable of detecting health-monitoring biomarkers with high sensitivity and specificity. Biosensors using nanomaterials are highly promising because of the wide detection range, fast response time, system miniaturization, and enhanced sensitivity. In the recent development of biosensors and electronics, graphene has rapidly gained popularity due to its superior electrical, biochemical, and mechanical properties. For biomarker detection, human saliva offers easy access with a large variety of analytes, making it a promising candidate for its use in point-of-care (POC) devices. Here, we report a comprehensive review that summarizes the most recent graphene-based nanobiosensors and oral bioelectronics for salivary biomarker detection. We discuss the details of structural designs of graphene electronics, use cases of salivary biomarkers, the performance of existing sensors, and applications in health monitoring. This review also describes current challenges in materials and systems and future directions of the graphene bioelectronics for clinical POC applications. Collectively, the main contribution of this paper is to deliver an extensive review of the graphene-enabled biosensors and oral electronics and their successful applications in human salivary biomarker detection.
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DOI：
10.1007/bf00539519
发表时间：
1977-01-01
期刊：
FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE
影响因子：
--
作者：
CAMMANN, K
通讯作者：
CAMMANN, K
影响因子：
8.4
作者：
Chekin, Fereshteh;Vasilescu, Alina;Szunerits, Sabine
通讯作者：
Szunerits, Sabine
影响因子：
4
作者：
Camara, N.;Rius, G.;Camassel, J.
通讯作者：
Camassel, J.
影响因子：
10.8
作者：
Balandin, Alexander A.;Ghosh, Suchismita;Lau, Chun Ning
通讯作者：
Lau, Chun Ning
影响因子：
2.1
作者：
Bolotin, K. I.;Sikes, K. J.;Stormer, H. L.
通讯作者：
Stormer, H. L.