Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery.
Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery.
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DOI：
10.1038/s41467-021-23962-8
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发表时间：
2021-06-25
影响因子：
16.6
通讯作者：
Sheiko SS
中科院分区：
文献类型：
--
作者：
Dashtimoghadam E;Fahimipour F;Keith AN;Vashahi F;Popryadukhin P;Vatankhah-Varnosfaderani M;Sheiko SS
目前用于生物医学设备的材料与组织的机械性能不匹配，并将各种化学物质渗入体内。这些缺陷会造成严重的健康风险，而侵入性植入手术会进一步加剧这些风险。在此，我们利用刷状聚合物结构来设计和施用微创可注射弹性体，其在体内固化成具有与周围组织匹配的机械性能的无粘性植入物。这种策略允许将固化时间从几分钟调整到几小时，这使得从快速伤口密封到时间密集型重建手术的广泛生物医学应用成为可能。这些可注射弹性体支持体外细胞增殖，同时还证明了体内植入物的完整性，具有轻度炎症反应和最小的纤维化包裹。生物医学应用需要与组织机械性能相匹配的微创材料。在本文中，作者报告了可以原位注射和固化的刷状聚合物，从而形成与周围组织机械混合并显示最小异物反应的弹性体植入物。
Current materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation. Minimally invasive materials that match tissues mechanical properties are needed for biomedical applications. Here, the authors report on brush-like polymers which can be injected and cured in situ, resulting in elastomeric implants which mechanically blend with surrounding tissue and show minimal foreign body response.
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影响因子：
28.1
作者：
Bose S;Volpatti LR;Thiono D;Yesilyurt V;McGladrigan C;Tang Y;Facklam A;Wang A;Jhunjhunwala S;Veiseh O;Hollister-Lock J;Bhattacharya C;Weir GC;Greiner DL;Langer R;Anderson DG
通讯作者：
Anderson DG
影响因子：
64.8
作者：
Green JJ;Elisseeff JH
通讯作者：
Elisseeff JH
影响因子：
5.5
作者：
Fetters, LJ;Lohse, DJ;Richter, D
通讯作者：
Richter, D
影响因子：
5.5
作者：
Dobrynin, Andrey V.;Carrillo, Jan-Michael Y.
通讯作者：
Carrillo, Jan-Michael Y.
影响因子：
4.3
作者：
Flassbeck, D;Pfleiderer, B;Hirner, AV
通讯作者：
Hirner, AV