Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes.
Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes.
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DOI：
10.1186/1757-4749-2-13
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发表时间：
2010-10-31
期刊：
影响因子：
4.2
通讯作者：
Yamaoka Y
中科院分区：
文献类型：
--
作者：
Shiota S;Matsunari O;Watada M;Hanada K;Yamaoka Y
2005年，第一个诱导十二指肠溃疡并对胃癌具有抑制作用的疾病特异性幽门螺杆菌毒力因子被鉴定，并被命名为十二指肠溃疡促进基因（dupA）。然而，dupA基因对临床结果的重要性在随后的研究中是相互矛盾的。本研究的目的是估计与dupA基因相关的临床结果的风险程度。对病例对照研究进行荟萃分析，这些研究提供了dupA阳性H。用聚合酶链反应检测pylori。在检索中识别了17项研究，共2，466例患者。感染dupA阳性的H.幽门螺杆菌使十二指肠溃疡的风险总体上增加了1.41倍（95%置信区间[CI]，1.12-1.76）。亚组分析显示，亚洲国家的汇总比值比（OR）为1.57（95%CI，1.19-2.06），西方国家为1.09（95%CI，0.73-1.62）。dupA基因的存在与胃癌和胃溃疡之间没有关联。不存在发表偏见。我们的荟萃分析证实了dupA基因的存在对十二指肠溃疡的重要性，特别是在亚洲国家。
In 2005, the first disease-specific Helicobacter pylori virulence factor that induced duodenal ulcer and had a suppressive action on gastric cancer has been identified, and was named duodenal ulcer promoting gene (dupA). However, the importance of the dupA gene on clinical outcomes is conflicting in subsequent studies. The aim of this study was to estimate the magnitude of the risk for clinical outcomes associated with dupA gene. A meta-analysis of case-control studies which provided raw data on the infection rates with the dupA-positive H. pylori detected by polymerase chain reaction was performed. Seventeen studies with a total of 2,466 patients were identified in the search. Infection with the dupA-positive H. pylori increased the risk for duodenal ulcer by 1.41-fold (95% confidence interval [CI], 1.12-1.76) overall. Subgroup analysis showed that the summary odds ratio (OR) was 1.57 (95% CI, 1.19-2.06) in Asian countries and 1.09 (95% CI, 0.73-1.62) in Western countries. There was no association between the presence of the dupA gene and gastric cancer and gastric ulcer. Publication bias did not exist. Our meta-analysis confirmed the importance of the presence of the dupA gene for duodenal ulcer, especially in Asian countries.
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中国幽门螺杆菌十二指肠溃疡促基因dupA
影响因子：
2.4
作者：
Zhang Z;Zheng Q;Chen X;Xiao S;Liu W;Lu H
通讯作者：
Lu H
影响因子：
6.4
作者：
Hussein, Nawfal R.;Argent, Richard H.;Atherton, John C.
通讯作者：
Atherton, John C.
DOI：
10.1007/s10096-010-0881-7
发表时间：
2010-04-01
影响因子：
4.5
作者：
Schmidt, H-M. A.;Andres, S.;Mitchell, H.
通讯作者：
Mitchell, H.
影响因子：
4.4
作者：
Arachchi, H. S. Jayasinghe;Kalra, Vijay;Ahuja, Vineet
通讯作者：
Ahuja, Vineet
影响因子：
3
作者：
Jose Matteo, Mario;Ines Armitano, Rita;Catalano, Mariana
通讯作者：
Catalano, Mariana