Homeostasis, regeneration and tumour formation in the mammalian epidermis.

Homeostasis, regeneration and tumour formation in the mammalian epidermis.
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DOI:
10.1387/ijdb.170341fw
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发表时间:
2018
期刊:
The International journal of developmental biology
影响因子:
--
通讯作者:
Watt FM
Watt FM
中科院分区:
其他
文献类型:
--
作者:
Belokhvostova D;Berzanskyte I;Cujba AM;Jowett G;Marshall L;Prueller J;Watt FM

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表皮是皮肤的外覆盖层,并在身体和环境之间提供保护界面。众所周知,表皮由自我更新和产生分化细胞的干细胞维持。在这篇综述中,我们讨论了最近的技术进步,包括单细胞转录组学和体内成像,提供了新的见解的性质和可塑性的干细胞室和不同的作用,干细胞在稳态,伤口修复和癌症。
The epidermis is the outer covering of the skin and provides a protective interface between the body and the environment. It is well established that the epidermis is maintained by stem cells that self-renew and generate differentiated cells. In this review, we discuss how recent technological advances, including single cell transcriptomics and in vivo imaging, have provided new insights into the nature and plasticity of the stem cell compartment and the differing roles of stem cells in homeostasis, wound repair and cancer.
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