Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles.
Behavioral and neuroendocrine consequences of disrupting a long-term monogamous social bond in aging prairie voles.
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DOI：
10.1080/10253890.2020.1812058
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Woodbury M
中科院分区：
文献类型：
--
作者：
Grippo AJ;McNeal N;Normann MC;Colburn W;Dagner A;Woodbury M
来自配偶，长期伴侣或提供情感或工具支持的人的社会支持可以防止衰老的后果，包括调解行为应激反应和改变短期应激反应的神经生物学过程。因此，长期的社会联系可能具有行为和神经生物学方面的益处。社会一夫一妻制的草原田鼠提供了一个有价值的实验模型，调查的好处，长期的社会债券对短期的压力反应在老龄化的动物，鉴于其独特的社会结构，形成持久的异性债券，生活在家庭群体，和双亲养育策略。男女对长期，同居草原田鼠的短期行为和神经内分泌应激反应进行了调查，无论是长期的社会配对（对照），或一段时间的社会隔离。在实验1中，社会隔离与急性游泳应激源的行为反应性改变，以及更大的神经激活下丘脑室旁核，以及特别是小细胞区域，游泳应激源（与对照）。在实验2中，社会隔离与更大的皮质酮反应后，急性约束应激（与配对）。未观察到性别差异。探索性相关性和亚组分析揭示了各种人口统计学变量（如受试者的年龄，一对同居在一起的时间量，以及一对一起饲养的窝数）与行为和神经内分泌结局指标之间的系统关系。这些发现可能有助于我们理解长期社会联系对调节短期行为和神经内分泌应激反应的益处。从长期的配偶或伴侣那里获得社会支持，或者从朋友那里获得强大的支持网络，可能对健康有重要的好处，特别是随着年龄的增长。在年老的一夫一妻制草原田鼠中，与长期社会伴侣的社会隔离会破坏行为和短期压力反应，而与长期伴侣生活在一起可以保护这些破坏。这项研究对于我们理解随着年龄的增长，社会支持对压力反应的好处很重要。
Social support from a spouse, long-term partner, or someone who provides emotional or instrumental support may protect against consequences of aging, including mediating behavioral stress reactivity and altering neurobiological process that underlie short-term stress responses. Therefore, long-term social bonding may have behavioral and neurobiological benefits. The socially monogamous prairie vole provides a valuable experimental model for investigating the benefits of long-term social bonds on short-term stress reactivity in aging animals, given their unique social structure of forming enduring opposite-sex bonds, living in family groups, and bi-parental rearing strategies. Male-female pairs of long-term, cohabitating prairie voles were investigated for short-term behavioral and neuroendocrine stress reactivity following either long-term social pairing (control), or a period of social isolation. In Experiment 1, social isolation was associated with altered behavioral reactivity to an acute swim stressor, and greater neural activation in the hypothalamic paraventricular nucleus, as well as specifically the parvocellular region, following the swim stressor (vs. control). In Experiment 2, social isolation was associated with greater corticosterone reactivity following an acute restraint stressor (vs. pairing). No sex differences were observed. Exploratory correlation and subgroup analyses revealed systematic relationships among various demographic variables (such as age of the subjects, amount of time the pair cohabitated together, and number of litters the pair reared together) and the behavioral and neuroendocrine outcome measures. These findings may inform our understanding of the benefits of long-term social bonding on modulating short-term behavioral and neuroendocrine responses to stress. Receiving social support from a long-term spouse or partner, or having a strong support network from friends, may have important health benefits, especially as people age. In aging monogamous prairie voles, social isolation from a long-term social partner disrupted behaviors and short-term stress responses, whereas living with a long-term partner protected against these disruptions. This research is important for our understanding of the benefits of social support on stress responses as we age.
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影响因子：
3.3
作者：
Grippo AJ;Ihm E;Wardwell J;McNeal N;Scotti MA;Moenk DA;Chandler DL;LaRocca MA;Preihs K
通讯作者：
Preihs K
影响因子：
3
作者：
CARTER, CS;GETZ, LL
通讯作者：
GETZ, LL
影响因子：
5
作者：
KAPLAN, GA;SALONEN, JT;PUSKA, P
通讯作者：
PUSKA, P
DOI：
10.1146/annurev-clinpsy-032816-045111
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
影响因子：
--
作者：
Kiecolt-Glaser, Janice K.;Wilson, Stephanie J.
通讯作者：
Wilson, Stephanie J.
影响因子：
4.2
作者：
Acevedo, Bianca P.;Aron, Arthur;Brown, Lucy L.
通讯作者：
Brown, Lucy L.