Structure and T cell inhibition properties of B7 family member, B7-H3.
Structure and T cell inhibition properties of B7 family member, B7-H3.
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DOI：
10.1016/j.str.2013.03.003
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发表时间：
2013-05-07
期刊：
影响因子：
5.7
通讯作者：
Almo, Steven C.
中科院分区：
文献类型：
--
作者：
Vigdorovich, Vladimir;Ramagopal, Udupi A.;Lazar-Molnar, Eszter;Sylvestre, Eliezer;Lee, Jun Sik;Hofmeyer, Kimberly A.;Zang, Xingxing;Nathenson, Stanley G.;Almo, Steven C.
T-cell activity is controlled by a combination of antigen-dependent signaling through the T-cell receptor and a set of auxiliary signals delivered through antigen-independent interactions, including the recognition of the B7 family of ligands. B7-H3 is a recently identified B7 family member that is strongly overexpressed in a range of cancers and correlates with poor prognosis. We report the crystal structure of murine B7-H3 at a 3-Å resolution, which provides a model for the organization of the IgV and IgC domains within the ectodomain. We demonstrate that B7-H3 inhibits T-cell proliferation and show that the FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules. This arrangement, in combination with previous reports, highlights the dynamic nature and plasticity of the immunoglobulin fold.
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