Genome-wide resolution peripheral blood methylome profiling reveals signatures for cholestatic liver disease.
Genome-wide resolution peripheral blood methylome profiling reveals signatures for cholestatic liver disease.
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DOI：
10.2217/epi-2020-0048
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发表时间：
2020-08
期刊：
影响因子：
3.8
通讯作者：
Lazaridis KN
中科院分区：
文献类型：
--
作者：
Moore RM;Sun Z;Juran BD;Lazaridis KN
探讨原发性胆管炎（PBC）和原发性硬化性胆管炎（PSC）的DNA甲基化改变。患者：通过还原亚硫酸氢盐测序对PBC、患有炎症性肠病（IBD）的PSC、没有IBD的PSC以及年龄、性别匹配的对照进行外周血甲基化组分析。检测并比较差异甲基化CpG（DMC）和差异甲基化区域（DMR）。我们确定了参与关键通路的疾病中一致改变的DMC和DMR。PSC的两种亚型之间存在许多相似之处，有趣的是PBC和PSC之间几乎没有相似之处。DMR与转录因子结合高度富集。在独立队列的肝组织中验证了最重要的DMC变化。甲基化组分析为PBC和PSC提供了见解。
To profile DNA methylation changes of primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Patients with: PBC, PSC with inflammatory bowel disease (IBD), PSC without IBD, and age-, sex-matched controls were profiled for methylomes of peripheral blood by reduced representation bisulfite sequencing. Differentially methylated CpG (DMC) and differentially methylated region (DMR) were detected and compared. We identified consistently altered DMCs and DMRs across diseases with involvement in key pathways. Many similarities noted between two subtypes of PSC, interestingly few existed between PBC and PSC. DMRs were highly enriched with transcription factor binding. Top DMC changes were validated in liver tissue of an independent cohort. Methylome profiling provides insights to PBC and PSC.
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16.6
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Forbes SJ
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Irizarry RA
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Tabibian, James H.;O'Hara, Steven P.;LaRusso, Nicholas F.
通讯作者：
LaRusso, Nicholas F.