Asymmetric development of the nervous system.

Asymmetric development of the nervous system.
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DOI:
10.1002/dvdy.24595
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发表时间:
2018-01
期刊:
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子:
--
通讯作者:
Chuang CF
Chuang CF
中科院分区:
其他
文献类型:
--
作者:
Alqadah A;Hsieh YW;Morrissey ZD;Chuang CF

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人类神经系统由看似对称的左右两部分组成。然而,仔细观察大脑会发现解剖和功能上的偏侧化。大脑不对称性缺陷与几种神经疾病相关,但我们对用于在人类中枢神经系统中建立偏侧化的机制的了解极其有限。在这里,我们回顾了人类和几种模式生物神经系统内的左右不对称,包括啮齿动物、斑马鱼、鸡、非洲爪哇、果蝇和线虫线虫。比较和对比神经系统中形成左右不对称的机制,可以让我们深入了解人类大脑是如何偏侧的。
The human nervous system consists of seemingly symmetric left and right halves. However, closer observation of the brain reveals anatomical and functional lateralization. Defects in brain asymmetry correlate with several neurological disorders, yet our understanding of the mechanisms used to establish lateralization in the human central nervous system is extremely limited. Here, we review left-right asymmetries within the nervous system of humans and several model organisms, including rodents, zebrafish, chickens, Xenopus, Drosophila, and the nematode Caenorhabditis elegans. Comparing and contrasting mechanisms used to develop left-right asymmetry in the nervous system can provide insight into how the human brain is lateralized.
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