Immunohistochemical characterization of parvalbumin-containing interneurons in the monkey basolateral amygdala.
Immunohistochemical characterization of parvalbumin-containing interneurons in the monkey basolateral amygdala.
复制标题
猴基底外侧杏仁核中含有小白蛋白的中间神经元的免疫组织化学特征。
DOI：
10.1016/j.neuroscience.2008.11.017
复制
发表时间：
2009-02-18
期刊：
影响因子：
3.3
通讯作者：
McDonald, A. J.
中科院分区：
文献类型：
--
作者：
Mascagni, F.;Muly, E. C.;Rainnie, D. G.;McDonald, A. J.
Interneurons expressing the calcium-binding protein parvalbumin (PV) are a critical component of the inhibitory circuitry of the basolateral nuclear complex (BLC) of the mammalian amygdala. These neurons form interneuronal networks interconnected by chemical and electrical synapses, and provide a strong perisomatic inhibition of local pyramidal projection neurons. Immunohistochemical studies in rodents have shown that most PV-positive (PV+) cells are GABAergic interneurons that co-express the calcium-binding protein calbindin (CB), but exhibit no overlap with interneuronal subpopulations containing the calcium-binding protein calretinin (CR) or neuropeptides. Despite the importance of identifying interneuronal subpopulations for clarifying the major players in the inhibitory circuitry of the BLC, very little is known about these subpopulations in primates. Therefore, in the present investigation dual-labeling immunofluorescence histochemical techniques were used to characterize PV+ interneurons in the basal and lateral nuclei of the monkey amygdala. These studies revealed that 90–94% of PV+ neurons were GABA+, depending on the nucleus, and that these neurons constituted 29–38 % of the total GABAergic population. CB+ and CR+ interneurons constituted 31–46% and 23–27%, respectively, of GABAergic neurons. Approximately one-quarter of PV+ neurons contained CB, and these cells constituted one-third of the CB+ interneuronal population. There was no colocalization of PV with the neuropeptides somatostatin or cholecystokinin, and virtually no colocalization with CR. These data indicate that the neurochemical characteristics of the PV+ interneuronal subpopulation in the monkey BLC are fairly similar to those seen in the rat, but there is far less colocalization of PV and CB in the monkey. These findings suggest that PV+ neurons are a discrete interneuronal subpopulation in the monkey BLC and undoubtedly play a unique functional role in the inhibitory circuitry of this brain region.
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影响因子：
16.2
作者：
Blatow, M;Rozov, A;Monyer, H
通讯作者：
Monyer, H
影响因子：
2.5
作者：
CARLSEN, J;HEIMER, L
通讯作者：
HEIMER, L
影响因子：
2.5
作者：
DELIMA, AD;MORRISON, JH
通讯作者：
MORRISON, JH
DOI：
10.1023/a:1024126110356
发表时间：
2002-03-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Kawaguchi, Y;Kondo, S
通讯作者：
Kondo, S
影响因子：
4
作者：
CELIO, MR;BAIER, W;GERDAY, C
通讯作者：
GERDAY, C