Microbiota disbiosis is associated with colorectal cancer.
Microbiota disbiosis is associated with colorectal cancer.
复制标题
微生物群失调与结直肠癌有关
DOI：
10.3389/fmicb.2015.00020
复制
发表时间：
2015
影响因子：
5.2
通讯作者：
Qin H
中科院分区：
文献类型：
--
作者：
Gao Z;Guo B;Gao R;Zhu Q;Qin H
人类肠道微生物群的生态失调与散发性结直肠癌（CRC）有关。本研究旨在研究结直肠癌患者肠道菌群分布特征。我们对16S rRNA基因V3区进行了基于焦磷酸测序的分析，以研究近端和远端CRC样本中癌组织和相邻非癌正常组织的微生物群。结果显示，结直肠癌患者和健康人的微生物结构存在显著差异。厚壁菌门和梭菌门在结直肠癌患者中的代表性过高，而变形菌门在结直肠癌患者中的代表性不足。此外，乳球菌和梭杆菌表现出相对较高的丰度，而假单胞菌和土氏志贺菌减少癌组织相比，相邻的非癌组织。同时，近端和远端结肠癌组织的总体微生物结构相似，但某些潜在的促癌病原体不同。这些结果表明，粘膜相关微生物群与CRC动态相关，这可能为微生物群相关的CRC诊断，预后，预防和治疗策略提供依据。
The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent non-cancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance while Pseudomonas and Escherichia-Shigella was reduced in cancerous tissues compared to adjacent non-cancerous tissues. Meanwhile, the overall microbial structures of proximal and distal colon cancerous tissues were similar; but certain potential pro-oncogenic pathogens were different. These results suggested that the mucosa-associated microbiota is dynamically associated with CRC, which may provide evidences for microbiota-associated diagnostic, prognostic, preventive, and therapeutic strategies for CRC.
登录
查看更多内容
影响因子：
3.6
作者：
He, Xuesong;Hu, Wei;Kaplan, Christopher W.;Guo, Lihong;Shi, Wenyuan;Lux, Renate
通讯作者：
Lux, Renate
影响因子：
158.5
作者：
DuPont, Herbert L.
通讯作者：
DuPont, Herbert L.
影响因子：
4.7
作者：
Huycke, MM;Abrams, V;Moore, DR
通讯作者：
Moore, DR
影响因子：
9.8
作者：
Neut, C;Bulois, P;Colombel, JF
通讯作者：
Colombel, JF
影响因子：
7
作者：
Castellarin, Mauro;Warren, Rene L.;Holt, Robert A.
通讯作者：
Holt, Robert A.