Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.
Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children.
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DOI：
10.1371/journal.pone.0051084
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Lewis SJ
中科院分区：
文献类型：
--
作者：
Bonilla C;Lawlor DA;Taylor AE;Gunnell DJ;Ben-Shlomo Y;Ness AR;Timpson NJ;St Pourcain B;Ring SM;Emmett PM;Smith AD;Refsum H;Pennell CE;Brion MJ;Smith GD;Lewis SJ
维生素B-12对健康神经系统的发育和维持至关重要。大脑发育主要发生在子宫内和婴儿早期，但孕期母体维生素B-12状态对后代认知功能的作用尚不清楚。在这项研究中，我们在英国出生队列（ALSPAC）中评估了营养良好的孕妇维生素B-12状况对其后代认知能力的影响。然后，我们研究了与血浆维生素B-12相关的母体基因FUT 2（rs 492602）和TCN 2（rs 1801198，rs 9606756）中的SNP与后代智商的关联。从观察上看，母亲维生素B-12摄入量与儿童智商呈正相关，在调整潜在混杂因素后，这种相关性明显减弱（母亲B-12摄入量加倍时，子女智商得分的平均差异，调整前：2.0（95% CI 1.3，2.8）;调整后：0.7（95% CI −0.04，1.4））。母亲FUT 2与后代智商弱相关：每个等位基因的智商平均差异为0.9（95% CI 0.1，1.6）。考虑到SNP与维生素B-12以及SNP与智商之间的关系，母体维生素B-12对后代智商的预期影响与观察结果一致。我们的研究结果表明，母亲的维生素B-12可能不会对后代的认知能力产生重要影响。然而，有必要进一步审查这一问题。
Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs492602) and TCN2 (rs1801198, rs9606756) that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child’s IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8); after adjustment: 0.7 (95% CI −0.04, 1.4)). Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6). The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted.
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影响因子：
5.2
作者：
Jones, RW;Ring, S;Golding, J
通讯作者：
Golding, J
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