Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.
Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.
复制标题
高效分层胶束整合光热疗法和单线态氧协同化疗来根除癌症
作者：
Wan Z;Mao H;Guo M;Li Y;Zhu A;Yang H;He H;Shen J;Zhou L;Jiang Z;Ge C;Chen X;Yang X;Liu G;Chen H
非常需要开发治疗诊断纳米颗粒，用于实现具有增强的对比度和同时的多模式协同治疗的癌症成像。在此，我们报告了一种分级组装花青染料（吲哚菁绿色）和化疗化合物（阿霉素）的治疗诊断胶束系统（I/D-胶束）作为一种新型的治疗诊断平台，具有高载药量，良好的稳定性和通过网格蛋白介导的内吞作用增强的细胞摄取。I/D-胶束具有近红外荧光（NIRF）、吲哚菁绿色的热疗和细胞内单线态氧以及阿霉素的细胞毒性等多种功能。在光照射时，I/D-胶束可以诱导NIRF成像、通过高热的急性光热治疗和通过单线态氧触发的溶酶体膜破坏的同时协同化疗，最终导致增强的NIRF成像和上级肿瘤根除而没有任何再生长。我们的研究结果表明，分层胶束可以作为一个上级治疗诊断平台的癌症成像和多模式协同治疗。
It is highly desirable to develop theranostic nanoparticles for achieving cancer imaging with enhanced contrast and simultaneously multimodal synergistic therapy. Herein, we report a theranostic micelle system hierarchically assembling cyanine dye (indocyanine green) and chemotherapeutic compound (doxorubicin) (I/D-Micelles) as a novel theranostic platform with high drug loading, good stability and enhanced cellular uptake via clathrin-mediated endocytosis. I/D-Micelles exhibit the multiple functionalities including near-infrared fluorescence (NIRF), hyperthermia and intracellular singlet oxygen from indocyanine green, and simultaneous cytotoxicity from doxorubicin. Upon photoirradiation, I/D-Micelles can induce NIRF imaging, acute photothermal therapy via hyperthermia and simultaneous synergistic chemotherapy via singlet oxygen-triggered disruption of lysosomal membranes, eventually leading to enhanced NIRF imaging and superior tumor eradication without any re-growth. Our results suggest that the hierarchical micelles can act as a superior theranostic platform for cancer imaging and multimodal synergistic therapy.
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影响因子：
17.1
作者：
Jang, Boseung;Park, Jin-Young;Choi, Yongdoo
通讯作者：
Choi, Yongdoo
DOI：
10.1016/s1011-1344(02)00325-1
发表时间：
2002-08-01
影响因子：
5.4
作者：
Kassab, K
通讯作者：
Kassab, K
影响因子：
16.6
作者：
Babin, Jerome;Pelletier, Maxime;Zhao, Yue
通讯作者：
Zhao, Yue
影响因子：
29.4
作者：
Huang, Peng;Lin, Jing;Wang, Xiansong;Wang, Zhe;Zhang, Chunlei;He, Meng;Wang, Kan;Chen, Feng;Li, Zhiming;Shen, Guangxia;Cui, Daxiang;Chen, Xiaoyuan
通讯作者：
Chen, Xiaoyuan
影响因子：
7.8
作者：
Escobedo, Jorge O.;Rusin, Oleksandr;Lim, Soojin;Strongin, Robert M.
通讯作者：
Strongin, Robert M.