Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila.
Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila.
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DOI：
10.1371/journal.pone.0131275
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Keene AC
中科院分区：
文献类型：
--
作者：
Slocumb ME;Regalado JM;Yoshizawa M;Neely GG;Masek P;Gibbs AG;Keene AC
动物通过调节睡眠和觅食策略来响应营养供应的变化，从而最大限度地提高健康水平。果蝇（果蝇）的野生种群表现出高度可变的饥饿和干燥抵抗能力，这些水平因地理位置、营养可用性和进化历史而异。此外，果蝇可以根据食物供应的变化有效调节睡眠，而对饥饿抵抗的选择可以增强睡眠，揭示了睡眠与营养供应之间的紧密遗传关系。为了确定睡眠与营养缺乏之间的遗传和进化关系，我们评估了选择用于干燥或饥饿抵抗力的果蝇的睡眠。虽然抗饥饿果蝇的甘油三酯水平较高，但抗干燥果蝇的糖原储备增加，表明对食物或水短缺的独特生理适应。引人注目的是，对饥饿抵抗的选择，而不是对干燥抵抗的选择，会导致睡眠增加，这表明睡眠增加并不是能量储存增加的普遍结果。饥饿或抗干燥果蝇的耐热性没有改变，这为针对环境压力源的特定环境适应提供了进一步的证据。通过将饥饿选择的果蝇与干燥选择的果蝇杂交产生F2杂交果蝇，并检查营养剥夺与睡眠之间的关系。杂交种在饥饿抵抗力和睡眠之间表现出正相关，而在干燥抵抗力和睡眠之间没有检测到相互作用，这表明延长睡眠提供了对饥饿应激的适应性反应。因此，这些发现证明了针对长期食物匮乏而增强睡眠的特定环境进化，并为理解睡眠与营养可用性之间的进化关系提供了模型。
Animals maximize fitness by modulating sleep and foraging strategies in response to changes in nutrient availability. Wild populations of the fruit fly, Drosophila melanogaster, display highly variable levels of starvation and desiccation resistance that differ in accordance with geographic location, nutrient availability, and evolutionary history. Further, flies potently modulate sleep in response to changes in food availability, and selection for starvation resistance enhances sleep, revealing strong genetic relationships between sleep and nutrient availability. To determine the genetic and evolutionary relationship between sleep and nutrient deprivation, we assessed sleep in flies selected for desiccation or starvation resistance. While starvation resistant flies have higher levels of triglycerides, desiccation resistant flies have enhanced glycogen stores, indicative of distinct physiological adaptations to food or water scarcity. Strikingly, selection for starvation resistance, but not desiccation resistance, leads to increased sleep, indicating that enhanced sleep is not a generalized consequence of higher energy stores. Thermotolerance is not altered in starvation or desiccation resistant flies, providing further evidence for context-specific adaptation to environmental stressors. F2 hybrid flies were generated by crossing starvation selected flies with desiccation selected flies, and the relationship between nutrient deprivation and sleep was examined. Hybrids exhibit a positive correlation between starvation resistance and sleep, while no interaction was detected between desiccation resistance and sleep, revealing that prolonged sleep provides an adaptive response to starvation stress. Therefore, these findings demonstrate context-specific evolution of enhanced sleep in response to chronic food deprivation, and provide a model for understanding the evolutionary relationship between sleep and nutrient availability.
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影响因子：
2.1
作者：
Hoffmann, AA;Hallas, R;Telonis-Scott, M
通讯作者：
Telonis-Scott, M
DOI：
10.1016/j.cub.2010.05.029
发表时间：
2010-07-13
期刊：
Current biology : CB
影响因子：
--
作者：
Keene AC;Duboué ER;McDonald DM;Dus M;Suh GS;Waddell S;Blau J
通讯作者：
Blau J
影响因子：
3.3
作者：
Chippindale, AK;Gibbs, AG;Rose, MR
通讯作者：
Rose, MR
影响因子：
1.6
作者：
Archer, Margaret A.;Bradley, Timothy J.;Rose, Michael R.
通讯作者：
Rose, Michael R.
影响因子：
3.3
作者：
Lee, GH;Park, JH
通讯作者：
Park, JH