Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo.
Parcellation of the Human Cerebral Cortex Based on Molecular Targets in the Serotonin System Quantified by Positron Emission Tomography In vivo.
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DOI：
10.1093/cercor/bhy249
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Lanzenberger R
中科院分区：
文献类型：
--
作者：
James GM;Gryglewski G;Vanicek T;Berroterán-Infante N;Philippe C;Kautzky A;Nics L;Vraka C;Godbersen GM;Unterholzner J;Sigurdardottir HL;Spies M;Seiger R;Kranz GS;Hahn A;Mitterhauser M;Wadsak W;Bauer A;Hacker M;Kasper S;Lanzenberger R
大脑皮层不同区域的分割在神经科学中有着悠久的历史，对于研究大脑功能、特化和神经精神疾病的改变具有重要价值。细胞结构特征的分析揭示了它们与基于蛋白质密度的分子谱密切相关。这为体内分子成像数据的使用提供了一个基本原理，可以利用全脑覆盖的优势对皮质进行包裹。在目前的工作中，包裹是基于5 -羟色胺神经递质系统的关键参与者的表达。采用正电子发射断层扫描，定量测定健康受试者血清素1A （5-HT1A, n = 30）和5-HT2A受体（n = 22）、血清素降解酶单胺氧化酶A （MAO-A, n = 32）和血清素转运体（5-HTT, n = 24）。采用表面定量法获得皮质蛋白分布图。基于k-means聚类、轮廓准则和自举，确定了5个不同的聚类作为最优解。这些定义的簇被证明对精神药物作用于血清素系统的作用具有很高的解释价值，如抗抑郁药和致幻剂。因此，该方法为神经药理学和精神病学的研究和发展提供了一种整合多模态成像数据的明智方法。
Parcellation of distinct areas in the cerebral cortex has a long history in neuroscience and is of great value for the study of brain function, specialization, and alterations in neuropsychiatric disorders. Analysis of cytoarchitectonical features has revealed their close association with molecular profiles based on protein density. This provides a rationale for the use of in vivo molecular imaging data for parcellation of the cortex with the advantage of whole-brain coverage. In the current work, parcellation was based on expression of key players of the serotonin neurotransmitter system. Positron emission tomography was carried out for the quantification of serotonin 1A (5-HT1A, n = 30) and 5-HT2A receptors (n = 22), the serotonin-degrading enzyme monoamine oxidase A (MAO-A, n = 32) and the serotonin transporter (5-HTT, n = 24) in healthy participants. Cortical protein distribution maps were obtained using surface-based quantification. Based on k-means clustering, silhouette criterion and bootstrapping, five distinct clusters were identified as the optimal solution. The defined clusters proved of high explanatory value for the effects of psychotropic drugs acting on the serotonin system, such as antidepressants and psychedelics. Therefore, the proposed method constitutes a sensible approach towards integration of multimodal imaging data for research and development in neuropharmacology and psychiatry.
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DOI：
10.1073/pnas.84.12.4322
发表时间：
1987-06-01
影响因子：
11.1
作者：
DAMATO, RJ;BLUE, ME;SNYDER, SH
通讯作者：
SNYDER, SH
影响因子：
5.7
作者：
Gryglewski, G.;Rischka, L.;Lanzenberger, R.
通讯作者：
Lanzenberger, R.
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
DOI：
10.1073/pnas.1308091110
发表时间：
2013-10-15
影响因子：
11.1
作者：
Chen, Chi-Hua;Fiecas, Mark;Kremen, William S.
通讯作者：
Kremen, William S.
影响因子：
5.3
作者：
Beliveau, Vincent;Ganz, Melanie;Knudsen, Gitte M.
通讯作者：
Knudsen, Gitte M.