The impact of the COVID-19 pandemic on negative symptoms in individuals at clinical high-risk for psychosis and outpatients with chronic schizophrenia.
The impact of the COVID-19 pandemic on negative symptoms in individuals at clinical high-risk for psychosis and outpatients with chronic schizophrenia.
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DOI：
10.1007/s00406-021-01260-0
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发表时间：
2022-03
影响因子：
4.7
通讯作者：
James SH
中科院分区：
文献类型：
--
作者：
Strauss GP;Macdonald KI;Ruiz I;Raugh IM;Bartolomeo LA;James SH
阴性症状是精神分裂症谱系疾病的核心特征，在疾病的各个阶段都经常观察到。就其本质而言，COVID-19 的社会隔离、身体距离和健康预防措施会诱发阴性症状的行为方面。然而，尚不清楚这些预防措施是否也会导致体验性阴性症状的增加，这种影响在各个阴性症状领域是否相同，以及在疾病的各个阶段是否相同地出现恶化。目前的研究将大流行期间获得的阴性症状严重程度评分与大流行前评估的两个样本进行了比较：（1）慢性精神分裂症门诊患者（SZ：n = 32）和匹配的健康对照（CN：n = 31）和（2）临床精神病高风险个体（CHR：n = 25）和匹配的CN（n = 30）。 SZ 组和 CHR 组的大流行前阴性症状评级在临床上有所升高，但其严重程度没有差异。在深圳，大流行期间获得的所有 5 个领域（失语、情感迟钝、快感缺乏、无欲和不社交）的评分均显着高于大流行前的评分，并且项目级分析表明，快感缺乏、无欲和不社交的体验和行为症状均出现恶化。相比之下，与预评级相比，CHR 在大流行期间仅表现出快感缺失和厌恶项目的增加。研究结果表明，在精神分裂症谱系中，阴性症状在大流行期间和之后应该是一个关键的治疗目标，因为它们正在恶化，并且与转化、功能结果和恢复的风险密切相关。
Negative symptoms are core features of schizophrenia-spectrum disorders that are frequently observed across all phases of illness. By their nature, COVID-19 social isolation, physical distancing, and health precautions induce behavioural aspects of negative symptoms. However, it is unclear whether these prevention measures also lead to increases in experiential negative symptoms, whether such effects are equivalent across individual negative symptom domains, and if exacerbations occur equivalently across phases of illness. The current study compared negative symptom severity scores obtained during the pandemic to pre-pandemic assessments in two samples: (1) outpatients with chronic schizophrenia (SZ: n = 32) and matched healthy controls (CN: n = 31) and (2) individuals at clinical high risk for psychosis (CHR: n = 25) and matched CN (n = 30). Pre-pandemic ratings of negative symptoms were clinically elevated in SZ and CHR groups, which did not differ from each other in severity. In SZ, ratings obtained during the pandemic were significantly higher than pre-pandemic ratings for all 5 domains (alogia, blunted affect, anhedonia, avolition, and asociality) and item-level analyses indicated that exacerbations occurred on both experiential and behavioral symptoms of anhedonia, avolition, and asociality. In contrast, CHR only exhibited increases in anhedonia and avolition items during the pandemic compared to pre-ratings. Findings suggest that negative symptoms should be a critical treatment target during and after the pandemic in the schizophrenia spectrum given that they are worsening and critically related to risk for conversion, functional outcome, and recovery.
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DOI：
10.1177/1745691620952789
发表时间：
2021-05
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
Gruber J;Mendle J;Lindquist KA;Schmader T;Clark LA;Bliss-Moreau E;Akinola M;Atlas L;Barch DM;Barrett LF;Borelli JL;Brannon TN;Bunge SA;Campos B;Cantlon J;Carter R;Carter-Sowell AR;Chen S;Craske MG;Cuddy AJC;Crum A;Davachi L;Duckworth AL;Dutra SJ;Eisenberger NI;Ferguson M;Ford BQ;Fredrickson BL;Goodman SH;Gopnik A;Greenaway VP;Harkness KL;Hebl M;Heller W;Hooley J;Jampol L;Johnson SL;Joormann J;Kinzler KD;Kober H;Kring AM;Paluck EL;Lombrozo T;Lourenco SF;McRae K;Monin JK;Moskowitz JT;Natsuaki MN;Oettingen G;Pfeifer JH;Prause N;Saxbe D;Smith PK;Spellman BA;Sturm V;Teachman BA;Thompson RJ;Weinstock LM;Williams LA
通讯作者：
Williams LA
影响因子：
4.5
作者：
Goldsmith DR;Haroon E;Miller AH;Strauss GP;Buckley PF;Miller BJ
通讯作者：
Miller BJ
影响因子：
6.6
作者：
Granholm, Eric;Holden, Jason;Worley, Matthew
通讯作者：
Worley, Matthew
影响因子：
6.7
作者：
CANIVE, JM;SANZFUENTENEBRO, J;TUASON, VB
通讯作者：
TUASON, VB
影响因子：
2
作者：
Clay, Kendall B.;Raugh, Ian M.;Strauss, Gregory P.
通讯作者：
Strauss, Gregory P.