Thyroid cancer following nuclear tests in French Polynesia.
Thyroid cancer following nuclear tests in French Polynesia.
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DOI：
10.1038/sj.bjc.6605862
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发表时间：
2010-09-28
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
1966至1974年间，法国在波利尼西亚进行了41次大气层核试验，但其潜在的健康影响此前并未得到调查。在一项病例对照研究中，我们将1981至2003年间几乎所有被诊断为分化型甲状腺癌的法属波利尼西亚人(n=229)的辐射暴露与373名普通人群中未患癌症的法属波利尼西亚人对照的辐射暴露进行了比较。使用核试验后的测量、每次试验时的年龄、居住和饮食信息来估计辐射暴露。15岁以前的平均甲状腺剂量约为1.8mGy.5%的病例和3%的对照组接受的剂量超过10 mGy.尽管剂量很低，但在调整了种族、教育水平、体表面积、甲状腺癌家族史和怀孕次数后，我们观察到，15岁之前接受的甲状腺剂量增加，患甲状腺癌的风险增加(P=0.04)，排除非侵袭性分化型甲状腺微小癌后，风险仍然存在。在后来经历四次或更多怀孕的女性中，单位甲状腺辐射剂量的风险增加比其他女性更高(P=0.03)。风险预估较低，但基于有限的曝险数据。目前被分类的暴露信息的公布将大大提高风险估计的可靠性。
Between 1966 and 1974, France conducted 41 atmospheric nuclear tests in Polynesia, but their potential health effects have not previously been investigated. In a case–control study, we compared the radiation exposure of almost all the French Polynesians diagnosed with differentiated thyroid carcinoma between 1981 and 2003 (n=229) to the exposure of 373 French Polynesian control individuals without cancer from the general population. Radiation exposures were estimated using measurements after the nuclear tests, age at time of each test, residential and dietary information. The average thyroid dose before 15 years of age was about 1.8 mGy, and 5% of the cases and 3% of the controls received a dose above 10 mGy. Despite this low level of dose, and after adjusting for ethnic group, level of education, body surface area, family history of thyroid cancer and number of pregnancies for women, we observed an increasing risk (P=0.04) of thyroid cancer with increasing thyroid dose received before age of 15 years, which remained after excluding non-aggressive differentiated thyroid micro-carcinomas. This increase of risk per unit of thyroid radiation dose was higher (P=0.03) in women who later experienced four or more pregnancies than among other women. The risk estimate is low, but is based on limited exposure data. The release of information on exposure, currently classified, would greatly improve the reliability of the risk estimation.
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