Cellulose, chitosan, and keratin composite materials. Controlled drug release.
Cellulose, chitosan, and keratin composite materials. Controlled drug release.
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DOI：
10.1021/la5034367
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发表时间：
2015-02-03
期刊：
影响因子：
--
通讯作者：
Mututuvari TM
中科院分区：
文献类型：
--
作者：
Tran CD;Mututuvari TM
在角蛋白（KER）中加入纤维素（CEL）和/或壳聚糖（CS），使[CEL/CS+KER]复合材料具有更好的机械强度和更广泛的应用。该方法采用离子液体[BMIm+Cl -]作为唯一溶剂，使用的[BMIm+Cl -]可回收，绿色环保，可循环利用。傅里叶变换红外光谱结果证实，KER、CS和CEL在复合材料中保持化学完整。拉伸强度结果表明，在KER中加入CEL或CS可显著提高复合材料的机械强度。我们发现CEL、CS和KER可以包封环丙沙星（CPX）等药物，然后以单组分或双组分或三组分的复合材料释放药物。有趣的是，CEL和CS单独或[CEL+CS]复合对CPX的释放速度更快，且与CS和CEL的浓度无关。相反，KER的释放速度要慢得多，当与CEL、CS或CEL+CS结合时，它也大大减慢了释放速度。此外，还发现还原速率与复合材料中KER的浓度有关。已知蛋白质KER具有二级结构，而CEL和CS仅以随机形式存在。这使得KER在结构上比CEL和CS更致密；因此，KER释放药物的速度比CEL和CS慢。结果清楚地表明，通过合理选择复合材料中KER的浓度，可以控制和调节药物的释放。此外，[CEL+CS+KER]复合材料具有其组分的综合特性，即优越的机械强度（CEL），止血和杀菌剂（CS）和控制药物释放（KER），这表明这种新型复合材料可以以迄今不可能的方式使用，例如，作为高性能绷带治疗慢性和溃疡性伤口。
A method was developed in which cellulose (CEL) and/or chitosan (CS) were added to keratin (KER) to enable [CEL/CS+KER] composites to have better mechanical strength and wider utilization. Butylmethylimmidazolium chloride ([BMIm+Cl–]), an ionic liquid, was used as the sole solvent, and because the [BMIm+Cl–] used was recovered, the method is green and recyclable. Fourier transform infrared spectroscopy results confirm that KER, CS, and CEL remain chemically intact in the composites. Tensile strength results expectedly show that adding CEL or CS into KER substantially increases the mechanical strength of the composites. We found that CEL, CS, and KER can encapsulate drugs such as ciprofloxacin (CPX) and then release the drug either as a single or as two- or three-component composites. Interestingly, release rates of CPX by CEL and CS either as a single or as [CEL+CS] composite are faster and independent of concentration of CS and CEL. Conversely, the release rate by KER is much slower, and when incorporated into CEL, CS, or CEL+CS, it substantially slows the rate as well. Furthermore, the reducing rate was found to correlate with the concentration of KER in the composites. KER, a protein, is known to have secondary structure, whereas CEL and CS exist only in random form. This makes KER structurally denser than CEL and CS; hence, KER releases the drug slower than CEL and CS. The results clearly indicate that drug release can be controlled and adjusted at any rate by judiciously selecting the concentration of KER in the composites. Furthermore, the fact that the [CEL+CS+KER] composite has combined properties of its components, namely, superior mechanical strength (CEL), hemostasis and bactericide (CS), and controlled drug release (KER), indicates that this novel composite can be used in ways which hitherto were not possible, e.g., as a high-performance bandage to treat chronic and ulcerous wounds.
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