Nanomedicine-Mediated Therapies to Target Breast Cancer Stem Cells.
Nanomedicine-Mediated Therapies to Target Breast Cancer Stem Cells.
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针对乳腺癌干细胞的纳米医学介导疗法
DOI：
10.3389/fphar.2016.00313
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发表时间：
2016
影响因子：
5.6
通讯作者：
Mo J
中科院分区：
文献类型：
--
作者：
He L;Gu J;Lim LY;Yuan ZX;Mo J
越来越多的证据表明，乳腺癌干细胞（BCSCs）的存在，具有自我更新和分化的潜力。BCSCs的来源可能与正常乳腺干细胞的发育有关。BCSC被认为在乳腺癌的发生、复发和化疗/放疗抗性中起关键作用。因此，消除BCSC对于乳腺癌治疗至关重要。然而，常规的化疗和放疗不能有效地根除BCSC。幸运的是，纳米技术在特异性和有效的抗BCSC治疗方面具有巨大的潜力。“智能”纳米载体可以将BCSC与其他乳腺癌细胞区分开来，并选择性地将治疗剂递送到BCSC。新的研究结果表明，乳腺癌中的BCSC可以被功能化纳米药物成功抑制甚至根除。在这篇综述中，我们专注于BCSC的起源，用于靶向BCSC的策略，并总结了基于纳米技术的递送系统已被应用于消除乳腺癌中的BCSC。
Accumulating evidences have suggested the existence of breast cancer stem cells (BCSCs), which possess the potential of both self-renewal and differentiation. The origin of BCSCs might have relationship to the development of normal mammary stem cells. BCSCs are believed to play a key role in the initiation, recurrence and chemo-/radiotherapy resistances of breast cancer. Therefore, elimination of BCSCs is crucial for breast cancer therapy. However, conventional chemo and radiation therapies cannot eradicate BCSCs effectively. Fortunately, nanotechnology holds great potential for specific and efficient anti-BCSCs treatment. “Smart” nanocarriers can distinguish BCSCs from the other breast cancer cells and selectively deliver therapeutic agents to the BCSCs. Emerging findings suggest that BCSCs in breast cancer could be successfully inhibited and even eradicated by functionalized nanomedicines. In this review, we focus on origin of BCSCs, strategies used to target BCSCs, and summarize the nanotechnology-based delivery systems that have been applied for eliminating BCSCs in breast cancer.
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影响因子：
14
作者：
Ganesh, Shanthi;Iyer, Arun K.;Morrissey, David V.;Amiji, Mansoor M.
通讯作者：
Amiji, Mansoor M.
影响因子：
17.1
作者：
Atkinson RL;Zhang M;Diagaradjane P;Peddibhotla S;Contreras A;Hilsenbeck SG;Woodward WA;Krishnan S;Chang JC;Rosen JM
通讯作者：
Rosen JM
影响因子：
14
作者：
Burke, Andrew R.;Singh, Ravi N.;Carroll, David L.;Wood, James C. S.;D'Agostino, Ralph B., Jr.;Ajayan, Pulickel M.;Torti, Frank M.;Torti, Suzy V.
通讯作者：
Torti, Suzy V.
影响因子：
3
作者：
Clarke, MF
通讯作者：
Clarke, MF
影响因子：
10.2
作者：
Chen H;Wang Y;Wang T;Shi D;Sun Z;Xia C;Wang B
通讯作者：
Wang B