The association of anti-annexin1 antibodies with the occurrence of skin lesions in systemic lupus erythematosus
The association of anti-annexin1 antibodies with the occurrence of skin lesions in systemic lupus erythematosus
复制标题
抗annexin1抗体与系统性红斑狼疮皮损发生的关系
作者：
米向斌
抗膜联蛋白1抗体与皮肤狼疮亚型相关，在系统性红斑狼疮（SLE）患者中升高。在这项研究中，我们调查了这种抗体与SLE皮肤病变的发病率的相关性。免疫印迹法检测抗膜联蛋白1-IgG和-IgM在健康对照组和SLE伴或不伴皮肤病变组中无显著性差异。血清抗膜联蛋白1-IgG和IgM的酶联免疫吸附测定法测定的患者和无皮肤病变之间是可比的，而抗膜联蛋白1-IgM在SLE患者低于健康对照组。Annexin 1在狼疮皮损的表皮各层中均大量表达。此外，抗膜联蛋白1-IgG在SLE伴关节炎患者中较高，且与白色血细胞（WBC）呈负相关。抗annexin 1-IgM在抗核抗体（ANA）阳性患者血清中较高，并与血红蛋白和血清总IgM呈正相关。总之，抗annexin 1抗体与SLE皮损的发生无关，annexin 1在皮损表皮中大量分布。
Anti-annexin1 antibodies are associated with the subtypes of cutaneous lupus and are elevated in systemic lupus erythematosus (SLE) patients. In this study, we investigated the correlation of this antibody with the incidence of SLE skin lesions. The presence of anti-annexin1-IgG and-IgM determined by Western blot was no different among healthy controls and SLE patients with and without skin lesions. Serum levels of anti-annexin1-IgG and -IgM measured by enzyme-linked immunosorbent assay were comparable between patients with and without skin lesions, whereas anti-annexin1-IgM was lower in SLE patients than in healthy controls. Annexin1 was abundantly detected in each epidermal layer in lupus lesional skin. Additionally, anti-annexin1-IgG was higher in SLE patients with arthritis and negatively correlated with white blood cells (WBC). Anti-annexin1-IgM was higher in patients with antinuclear antibody (ANA)-positive sera, and was positively related to hemoglobin and total serum IgM. Collectively, anti-annexin1 antibodies are not related to the incidence of skin lesions in SLE, and annexin1 abundantly distributes in epidermis in lesional skin.
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影响因子：
4.6
作者：
Huitinga;Bauer;Strijbos;Rothwell;Dijkstra;Tilders
通讯作者：
Huitinga;Bauer;Strijbos;Rothwell;Dijkstra;Tilders
DOI：
10.1111/1523-1747.ep12371684
发表时间：
1993-11
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
R. Fava;L. Nanney;D. Wilson;L. King
通讯作者：
R. Fava;L. Nanney;D. Wilson;L. King
影响因子：
11.8
作者：
Arur, S;Uche, UE;Han, DK
通讯作者：
Han, DK
DOI：
--
发表时间：
1991-08
期刊：
The Journal of rheumatology
影响因子：
--
作者：
K. Duffy;C. Duffy;D. Gladman
通讯作者：
K. Duffy;C. Duffy;D. Gladman
影响因子：
5
作者：
S. Probst‐Cousin;D. Kowolik;K. Kuchelmeister;C. Kayser;B. Neundörfer;D. Heuss
通讯作者：
S. Probst‐Cousin;D. Kowolik;K. Kuchelmeister;C. Kayser;B. Neundörfer;D. Heuss