Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Stem Cells in Subacute Ischemic Stroke Patients.
Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Stem Cells in Subacute Ischemic Stroke Patients.
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DOI：
10.3389/fneur.2016.00228
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发表时间：
2016
影响因子：
3.4
通讯作者：
ElZamarany EA
中科院分区：
文献类型：
--
作者：
Ghali AA;Yousef MK;Ragab OA;ElZamarany EA
基于许多临床前和小型临床试验，干细胞可以帮助中风患者替代细胞并支持剩余细胞的可能性。本研究的目的是评估骨髓单个核（BMMN）干细胞移植治疗亚急性缺血性脑卒中患者的安全性和可行性。招募了39例（n = 39）大脑中动脉（MCA）区域大动脉闭塞所致亚急性缺血性脑梗死患者。他们被分为两组：第一组（n = 21）作为实验组，接受动脉内（IA）单核干细胞（骨髓来源的单核细胞），而另一组（n = 18）作为对照组。采用美国国立卫生研究院卒中量表、改良兰金量表、Barthel指数、改良标准化的阿拉伯语版综合失语症测验及影像学检查对患者进行12个月的临床评估。干细胞治疗组表现出更好的改善，但与未治疗组相比并不显著。研究结束时两组的梗死体积变化无显著性差异。干细胞治疗组无不良反应或不良反应轻微。研究结果表明，自体BMMN干细胞IA移植治疗亚急性MCA缺血性卒中患者是安全的，危害极小，但与未治疗组相比，干细胞治疗组未检测到运动、语言障碍或梗死体积的显著改善。
Based on many preclinical and small clinical trials, stem cells can help stroke patient with the possibility of replacing the cells and supporting the remaining cells. The aim of this study was to evaluate the safety and feasibility of bone marrow mononuclear (BMMN) stem cell transplantation in subacute ischemic stroke patients. Thirty-nine (n = 39) patients with subacute ischemic cerebral infarct due to large artery occlusion in the middle cerebral artery (MCA) territory were recruited. They were distributed into two groups: first group (n = 21) served as an experimental group, which received intra-arterial (IA) mononuclear stem cells (bone marrow-derived mononuclear cell), while the other group (n = 18) served as a control group. All the patients were evaluated clinically by National Institutes of Health Stroke Scale, modified Rankin Scale, Barthel Index, modified and standardized Arabic version of the Comprehensive Aphasia Test, and radiological for 12 months. The stem cell-treated group showed better improvement, but it was not significant when compared with the non-treated group. The volume of infarction changes at the end of the study was non-significant between both the groups. There was no, or minimal, adverse reactions in stem cell-treated group. The study results suggest that autologous BMMN stem cell IA transplantation in subacute MCA ischemic stroke patients is safe with very minimal hazards, but no significant improvement of motor, language disturbance, or infarction volume was detected in stem cell-treated group compared with the non-treated group.
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影响因子：
8.3
作者：
Jauch, Edward C.;Saver, Jeffrey L.;Yonas, Howard
通讯作者：
Yonas, Howard
影响因子：
8.3
作者：
Moniche, Francisco;Gonzalez, Alejandro;Gil-Peralta, Alberto
通讯作者：
Gil-Peralta, Alberto
影响因子：
8.3
作者：
Modo, M;Stroemer, P;Hodges, H
通讯作者：
Hodges, H
影响因子：
2.8
作者：
Suarez-Monteagudo, Carlos;Hernandez-Ramirez, Porfirio;Bergado, Jorge A.
通讯作者：
Bergado, Jorge A.
影响因子：
--
作者：
Hao L;Zou Z;Tian H;Zhang Y;Zhou H;Liu L
通讯作者：
Liu L