The science of neural interface systems.
The science of neural interface systems.
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DOI：
10.1146/annurev.neuro.051508.135241
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发表时间：
2009
影响因子：
13.9
通讯作者：
Donoghue JP
中科院分区：
文献类型：
--
作者：
Hatsopoulos NG;Donoghue JP
神经接口研究的最终目标是通过刺激或记录神经组织来建立神经系统与外界之间的联系，以治疗或帮助患有感觉、运动或其他神经功能障碍的人。尽管电刺激系统已经广泛应用于临床，但记录神经信号以破译运动意图的神经接口现在才开始发展成为临床上可行的系统来帮助瘫痪患者。我们首先回顾最先进的研究和早期临床记录系统，并重点关注记录单单位动作电位的系统。然后，我们通过在神经编码和表征、可塑性、大脑行为关系和疾病神经生物学方面提供独特的见解，探讨神经接口研究增强对大脑功能的基本科学理解的潜力。最后，我们讨论这些系统在被严重运动障碍患者广泛采用之前所面临的技术和科学挑战。
The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of neural function. Although electrical stimulation systems have already reached widespread clinical application, neural interfaces that record neural signals to decipher movement intentions are only now beginning to develop into clinically viable systems to help paralyzed people. We begin by reviewing state-of-the-art research and early-stage clinical recording systems and focus on systems that record single-unit action potentials. We then address the potential for neural interface research to enhance basic scientific understanding of brain function by offering unique insights in neural coding and representation, plasticity, brain-behavior relations, and the neurobiology of disease. Finally, we discuss technical and scientific challenges faced by these systems before they are widely adopted by severely motor-disabled patients.
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影响因子：
5.7
作者：
Beisteiner, R;Windischberger, C;Deecke, L
通讯作者：
Deecke, L
影响因子：
5.9
作者：
Arle, JE;Alterman, RL
通讯作者：
Alterman, RL
影响因子：
5.3
作者：
Fagg, Andrew H.;Hatsopoulos, Nicholas G.;Miller, Lee E.
通讯作者：
Miller, Lee E.
DOI：
10.1073/pnas.94.1.1
发表时间：
1997-01-07
影响因子：
11.1
作者：
Bullock, TH
通讯作者：
Bullock, TH
影响因子：
2.5
作者：
Brockwell, AE;Rojas, AL;Kass, RE
通讯作者：
Kass, RE