Hypocapnia decreases the amount of rapid eye movement sleep in cats.
Hypocapnia decreases the amount of rapid eye movement sleep in cats.
复制标题
低碳酸血症会减少猫的快速动眼睡眠时间。
作者：
Lovering,AndrewT;Fraigne,JimmyJ;Dunin-Barkowski,WitaliL;Vidruk,EdwardH;Orem,JohnM
睡眠在高海拔地区会受到干扰。高海拔地区的低Po 2水平会导致过度换气，导致继发性低碳酸血症（低Paco 2水平）。因此，虽然在高海拔地区的睡眠中断通常被认为是由缺氧引起的，它可能反而是低碳酸血症的结果。ObjectiveDetermination whether hypocapnia disrupts sleep.MethodsFour cats were studied for a total of 345 hours of sleep recordings.有两种方法被用来测试这个想法。首先，我们研究了猫在呼吸相当于大约12,000英尺和21,000英尺的氧气浓度（15%和10%）时的睡眠。然后，我们再次研究了他们对同样的低氧刺激的睡眠反应，但在吸气中加入CO2以维持正常的CO2水平。结果低氧（10%O2）使快动眼睡眠减少到正常的20%左右，而补充CO2使快动眼睡眠恢复到正常的70%左右。在睡眠缺氧期间未观察到周期性呼吸和呼吸暂停。当机械过度通气降低CO2的85%，75%，和65%的正常，快速眼动睡眠逐渐下降，从控制水平的17%的总记录时间为12%，7%，和4%.ConclusionWe的结论是，低碳酸血症，而不是缺氧可能占大多数的睡眠障碍在高海拔地区。
ContextSleep is disturbed at high altitudes. Low Po2levels at high altitude cause hyperventilation, which results in secondary hypocapnia (low Paco2levels). Thus, although sleep disruption at high altitudes is generally assumed to be caused by hypoxia, it may instead be the result of hypocapnia.ObjectiveTo determine whether hypocapnia disrupts sleep.MethodsFour cats were studied for a total of 345 hours of sleep recordings. Two methods were used to test this idea. First we studied their sleep when the cats breathed oxygen concentrations (15% and 10%) equivalent to those at approximately 12,000 feet and 21,000 feet. Then we studied their sleep again in response to the same hypoxic stimuli but with CO2added to the inspirate to maintain normal CO2levels. Second, we used mechanical hyperventilation to vary the levels of CO2while maintaining normal O2levels.ResultsHypoxia (10% O2) decreased the amount of rapid eye movement sleep to about 20% of normal, and adding back CO2restored rapid eye movement sleep to approximately 70% of normal. Periodic breathing and apneas were not observed during hypoxia in sleep. When mechanical hyperventilation lowered the CO2to 85%, 75%, and 65% of normal, rapid eye movement sleep decreased progressively from a control level of 17% of total recording time to 12%, 7%, and 4%, respectively.ConclusionWe conclude that hypocapnia rather than hypoxia may account for most of the sleep disturbance at high altitudes.
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刷尾负鼠 (Trychosurus vulpecula Kerr) 幼仔的气体环境
影响因子：
1.9
作者：
S. Bailey;G. Dunnet
通讯作者：
G. Dunnet
高海拔对人的一些影响。
影响因子：
168.9
作者：
L. Pugh;M. Ward
通讯作者：
M. Ward
在高海拔地区
DOI：
10.1017/s0368393100107771
发表时间：
1937
期刊：
The Journal of the Royal Aeronautical Society
影响因子：
--
作者：
F. W. Lanchester
通讯作者：
F. W. Lanchester
缺氧期间完整和颈动脉窦神经切片的大鼠的睡眠-觉醒模式。
影响因子：
5.6
作者：
T. Ryan Ann;David Megirian
通讯作者：
David Megirian
影响因子：
3.3
作者：
Lovering, AT;Dunin-Barkowski, WL;Orem, JM
通讯作者：
Orem, JM