Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases.
Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases.
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DOI：
10.1155/2018/9734845
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发表时间：
2018
影响因子：
4.6
通讯作者：
Ortuño-Sahagún D
中科院分区：
文献类型：
--
作者：
Carrera-Quintanar L;López Roa RI;Quintero-Fabián S;Sánchez-Sánchez MA;Vizmanos B;Ortuño-Sahagún D
肠道微生物群（GM）在宿主生理学中起着几个关键作用，并影响着几个相关功能。在不止一个方面，可以说你“喂养你的微生物群，并由它喂养”。转基因多样性受饮食影响，并影响宿主生理的代谢和免疫功能。因此，GM的不平衡或生态失调可能是各种病理学的原因或至少可能导致各种病理学的进展，例如感染性疾病、胃肠癌、炎症性肠病，甚至肥胖和糖尿病。因此，转基因是改善健康的营养干预措施的适当目标。出于这个原因，可以影响转基因的植物化学物质最近被研究作为治疗肥胖和炎症性疾病的佐剂。植物化学物质包括益生元和益生菌，以及几种化合物，如多酚及其衍生物、类胡萝卜素和硫代硫酸盐。其中最大的一组包括多酚，其可以细分为四个主要组：类黄酮（包括八个亚组），酚酸（如姜黄素），芪类化合物（如白藜芦醇）和木脂素。因此，在这篇综述中，我们将提出，组织和讨论最新的证据表明，不同的植物化学物质对影响肥胖和/或炎症的转基因的影响之间的关系，重点是大约40种不同的植物化学化合物的影响，这些化合物已经被化学鉴定，并构成一些天然水库，如潜在的促炎剂，作为治疗肥胖症和炎性疾病的候选物。
Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you “feed your microbiota and are fed by it.” GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health. For this reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical compounds such as polyphenols and derivatives, carotenoids, and thiosulfates. The largest group of these comprises polyphenols, which can be subclassified into four main groups: flavonoids (including eight subgroups), phenolic acids (such as curcumin), stilbenoids (such as resveratrol), and lignans. Consequently, in this review, we will present, organize, and discuss the most recent evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that have been chemically identified and that constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases.
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影响因子：
8.9
作者：
Aggarwal BB
通讯作者：
Aggarwal BB
影响因子：
4.8
作者：
Assini, Julia M.;Mulvihill, Erin E.;Huff, Murray W.
通讯作者：
Huff, Murray W.
影响因子：
--
作者：
Asgary, Sedigheh;Rafieian-Kopaei, Mahmoud;Sahebkar, Amirhossein
通讯作者：
Sahebkar, Amirhossein
影响因子：
5.4
作者：
Cavendish, Rodrigo Lima;Santos, Jandson de Souza;Gomes, Margarete Zanardo
通讯作者：
Gomes, Margarete Zanardo
影响因子：
4
作者：
ADOGA, GI
通讯作者：
ADOGA, GI