Using genomic prediction to detect microevolutionary change of a quantitative trait.

Using genomic prediction to detect microevolutionary change of a quantitative trait.
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DOI:
10.1098/rspb.2022.0330
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发表时间:
2022-05-11
影响因子:
4.7
通讯作者:
Slate, J.
Slate, J.
中科院分区:
生物学1区
文献类型:
--
作者:
Hunter, D. C.;Ashraf, B.;Berenos, C.;Ellis, P. A.;Johnston, S. E.;Wilson, A. J.;Pilkington, J. G.;Pemberton, J. M.;Slate, J.

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通过观察个体育种值的时间变化来检测自然选择的微进化反应是具有挑战性的。收集合适的数据集可能需要多年时间,并且解开环境和遗传对表型变化的贡献并不是微不足道的。此外,获得个体育种值的基于谱系的方法具有已知的偏差。在这里,我们应用基因组预测方法来估计育种值的成年体重在35年的数据集Soay羊(Ovis aries)。与传统的基于谱系的方法进行比较。在研究期间,成年体重下降,但体重的潜在遗传成分增加,其速度不太可能归因于遗传漂变。因此,可能发生了成年体重增加的隐性微进化。基于基因组和谱系的方法得到了基本一致的结果。因此,使用基因组预测来研究野生种群的微进化可以消除对谱系数据的要求,可能为类似的研究开辟新的研究系统。
Detecting microevolutionary responses to natural selection by observing temporal changes in individual breeding values is challenging. The collection of suitable datasets can take many years and disentangling the contributions of the environment and genetics to phenotypic change is not trivial. Furthermore, pedigree-based methods of obtaining individual breeding values have known biases. Here, we apply a genomic prediction approach to estimate breeding values of adult weight in a 35-year dataset of Soay sheep (Ovis aries). Comparisons are made with a traditional pedigree-based approach. During the study period, adult body weight decreased, but the underlying genetic component of body weight increased, at a rate that is unlikely to be attributable to genetic drift. Thus cryptic microevolution of greater adult body weight has probably occurred. Genomic and pedigree-based approaches gave largely consistent results. Thus, using genomic prediction to study microevolution in wild populations can remove the requirement for pedigree data, potentially opening up new study systems for similar research.
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