Aging and gastrointestinal neuromuscular function: insights from within and outside the gut.
Aging and gastrointestinal neuromuscular function: insights from within and outside the gut.
复制标题
衰老与胃肠道神经肌肉功能：来自肠道内外的见解
DOI：
10.1111/j.1365-2982.2011.01678.x
复制
发表时间：
2011-06
影响因子：
3.5
通讯作者：
Wiley JW
中科院分区：
文献类型：
--
作者：
Bitar K;Greenwood-Van Meerveld B;Saad R;Wiley JW
研究背景在没有全身性疾病的情况下，通常与使用可影响脑-肠轴的药物有关，脑-肠轴的临床显著变化通常在70岁之前不明显。3味觉和嗅觉的改变、胃动力、肠道细菌过度生长的增加以及GI激素和神经递质水平的变化可能有助于在老年观察到的生理性厌食症。吞咽改变导致无症状误吸，以及胃排空改变可能导致餐后低血压和消化不良。盆腔底和肛门直肠的结构和功能的改变可能是老年人便秘和大便失禁的主要原因，而与年龄相关的结肠肌壁的弱化可能有助于憩室病的发展。4最后，合并症（如心血管疾病、高血压和糖尿病）的临床影响及其治疗可能会对GI神经肌肉功能产生显著影响，但该问题尚未明确。5
BackgroundIn the absence of systemic diseases that are often associated with the use of medications that can affect the brain-gut axis, clinically-significant changes in the brain-gut axis are typically not apparent prior to the seventh decade of life. 3 Alterations in taste and smell, gastric motility, increased presence in bacterial intestinal overgrowth and changes in GI hormone and neurotransmitter levels may contribute to physiological anorexia observed in advanced age. Alterations in swallowing leading to silent aspiration, as well as changes in gastric emptying may contribute to postprandial hypotension and maldigestion. Age-related alterations in the structure and function of the pelvic floor and anorectum may be a major contributor to the constipation and fecal incontinence encountered in the elderly, and age-associated weakening of the colonic muscular wall may contribute to the development of diverticulosis. 4 Finally, the clinical impact of co-morbid conditions such as cardiovascular disease, hypertension and diabetes mellitus, and their treatment are likely to have a significant effect on GI neuromuscular function but this issue remains undefined. 5
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影响因子：
3.9
作者：
Bartke, Andrzej
通讯作者：
Bartke, Andrzej
DOI：
10.1046/j.1365-2281.2001.00308.x
发表时间：
2001-03-01
期刊：
CLINICAL PHYSIOLOGY
影响因子：
--
作者：
Graff, J;Brinch, K;Madsen, JL
通讯作者：
Madsen, JL
DOI：
10.1111/j.1440-1746.2008.05561.x
发表时间：
2009-01-01
影响因子：
4.1
作者：
Andrews, Jane M.;Heddle, Richard;Fraser, Robert J.
通讯作者：
Fraser, Robert J.
影响因子：
5.3
作者：
Greene, James G.;Noorian, Ali Reza;Srinivasan, Shanthi
通讯作者：
Srinivasan, Shanthi
影响因子：
9.9
作者：
Abbott, RD;Petrovitch, H;Ross, GW
通讯作者：
Ross, GW