Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction.
Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction.
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药物使用障碍的神经发育起源：早期逆境和成瘾动物模型的证据。
DOI：
10.1111/ejn.15223
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发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
Mahler SV
中科院分区：
文献类型：
--
作者：
Levis SC;Baram TZ;Mahler SV
成瘾是一种慢性复发性疾病，会对个人、社会和经济造成毁灭性后果。对于人类来说，创伤、忽视和资源匮乏等早年逆境（ELA）与晚年成瘾风险增加有关，但这种联系背后的大脑机制仍然知之甚少。在这里，我们重点关注来自 ELA 和成瘾的啮齿动物模型的数据，其中可以确定 ELA 对晚年药物反应的因果影响，以及 ELA 增加成瘾脆弱性的神经发育机制。我们首先总结了 ELA 与人类成瘾之间存在联系的证据，然后描述了 ELA 通常如何在啮齿类动物中建模。由于成瘾是一种异质性疾病，许多个体行为方面可能受到 ELA 的影响，因此我们接下来讨论成瘾样行为的常见啮齿动物检测。然后，我们总结了 ELA 在雄性和雌性啮齿动物中引起的与成瘾相关的特定行为表型，并讨论了可能造成这种情况的大脑奖励和压力回路的一些潜在变化。通过更好地了解 ELA 促进成瘾脆弱性的行为和神经机制，我们希望促进开发新方法来预防或治疗有 ELA 病史的人成瘾。
Addiction is a chronic relapsing disorder with devastating personal, societal, and economic consequences. In humans, early-life adversity (ELA) such as trauma, neglect, and resource scarcity are linked with increased risk of later-life addiction, but the brain mechanisms underlying this link are still poorly understood. Here, we focus on data from rodent models of ELA and addiction, in which causal effects of ELA on later-life responses to drugs and the neurodevelopmental mechanisms by which ELA increases vulnerability to addiction can be determined. We first summarize evidence for a link between ELA and addiction in humans, then describe how ELA is commonly modeled in rodents. Since addiction is a heterogeneous disease with many individually varying behavioral aspects that may be impacted by ELA, we next discuss common rodent assays of addiction-like behaviors. We then summarize the specific addiction-relevant behavioral phenotypes caused by ELA in male and female rodents and discuss some of the underlying changes in brain reward and stress circuits that are likely responsible. By better understanding the behavioral and neural mechanisms by which ELA promotes addiction vulnerability, we hope to facilitate development of new approaches for preventing or treating addiction in those with a history of ELA.
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DOI：
10.1111/ejn.12866
发表时间：
2015-05
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Bentzley BS;Aston-Jones G
通讯作者：
Aston-Jones G
影响因子：
3.3
作者：
Andersen SL
通讯作者：
Andersen SL
影响因子：
5
作者：
Bath KG;Nitenson AS;Lichtman E;Lopez C;Chen W;Gallo M;Goodwill H;Manzano-Nieves G
通讯作者：
Manzano-Nieves G
影响因子：
3.4
作者：
Bentzley, Brandon S.;Fender, Kimberly M.;Aston-Jones, Gary
通讯作者：
Aston-Jones, Gary
影响因子：
8.2
作者：
Baracz, Sarah J.;Everett, Nicholas A.;Cornish, Jennifer L.
通讯作者：
Cornish, Jennifer L.