Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic.
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is common in post-acute sequelae of SARS-CoV-2 infection (PASC): Results from a post-COVID-19 multidisciplinary clinic.
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DOI：
10.3389/fneur.2023.1090747
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发表时间：
2023
影响因子：
3.4
通讯作者：
Geng, Linda C. C.
中科院分区：
文献类型：
--
作者：
Bonilla, Hector;Quach, Tom C. C.;Tiwari, Anushri;Bonilla, Andres E. E.;Miglis, Mitchell;Yang, Phillip C. C.;Eggert, Lauren E. E.;Sharifi, Husham;Horomanski, Audra;Subramanian, Aruna;Smirnoff, Liza;Simpson, Norah;Halawi, Houssan;Sum-ping, Oliver;Kalinowski, Agnieszka;Patel, Zara M. M.;Shafer, Robert William;Geng, Linda C. C.
PASC的全球患病率估计为0·43，根据世卫组织估计的全球4.7亿COVID-19感染，相当于约2亿人经历长期COVID症状。尽管如此，其临床特征并不明确。我们从COVID-19后诊所的140名PASC患者中收集了人口统计学、风险因素、疾病严重程度（分级为1-轻度至5-重度）、功能状态以及29种症状和主成分症状聚类分析的回顾性数据。使用医学研究所（IOM）2015标准确定脑脊髓炎/慢性疲劳综合征（ME/CFS）表型。中位年龄为47岁，59.0%为女性; 49.3%为白色，17.2%为西班牙裔，14.9%为亚裔，6.7%为黑人。只有12.7%需要住院治疗。72例（53.5%）患者没有已知的合并症。45例（33.9%）患者明显虚弱。中位症状持续时间为285.5天，症状数量为12。最常见的症状是疲劳（86.5%）、运动后不适（82.8%）、脑雾（81.2%）、睡眠不振（76.7%）和嗜睡（74.6%）。43%的患者符合ME/CFS的标准，大多数为女性，肥胖（BMI > 30 Kg/m2）（P = 0.00377895）和较差的功能状态（P = 0.0110474）与ME/CFS显著相关。在我们诊所接受评估的大多数PASC患者没有合并症，也没有因急性COVID-19住院。三分之一的患者经历了严重的功能状态下降。约43%有ME/CFS亚型。
The global prevalence of PASC is estimated to be present in 0·43 and based on the WHO estimation of 470 million worldwide COVID-19 infections, corresponds to around 200 million people experiencing long COVID symptoms. Despite this, its clinical features are not well-defined. We collected retrospective data from 140 patients with PASC in a post-COVID-19 clinic on demographics, risk factors, illness severity (graded as one-mild to five-severe), functional status, and 29 symptoms and principal component symptoms cluster analysis. The Institute of Medicine (IOM) 2015 criteria were used to determine the Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) phenotype. The median age was 47 years, 59.0% were female; 49.3% White, 17.2% Hispanic, 14.9% Asian, and 6.7% Black. Only 12.7% required hospitalization. Seventy-two (53.5%) patients had no known comorbid conditions. Forty-five (33.9%) were significantly debilitated. The median duration of symptoms was 285.5 days, and the number of symptoms was 12. The most common symptoms were fatigue (86.5%), post-exertional malaise (82.8%), brain fog (81.2%), unrefreshing sleep (76.7%), and lethargy (74.6%). Forty-three percent fit the criteria for ME/CFS, majority were female, and obesity (BMI > 30 Kg/m2) (P = 0.00377895) and worse functional status (P = 0.0110474) were significantly associated with ME/CFS. Most PASC patients evaluated at our clinic had no comorbid condition and were not hospitalized for acute COVID-19. One-third of patients experienced a severe decline in their functional status. About 43% had the ME/CFS subtype.
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影响因子：
15.1
作者：
Bahmer, Thomas;Borzikowsky, Christoph;Lieb, Wolfgang;Horn, Anna;Krist, Lilian;Fricke, Julia;Scheibenbogen, Carmen;Rabe, Klaus F.;Maetzler, Walter;Maetzler, Corina;Laudien, Martin;Frank, Derk;Ballhausen, Sabrina;Hermes, Anne;Miljukov, Olga;Haeusler, Karl Georg;El Mokhtari, Nour Eddine;Witzenrath, Martin;Vehreschild, Joerg Janne;Krefting, Dagmar;Pape, Daniel;Montellano, Felipe A.;Kohls, Mirjam;Morbach, Caroline;Stork, Stefan;Reese, Jens-Peter;Keil, Thomas;Heuschmann, Peter;Krawczak, Michael;Schreiber, Stefan
通讯作者：
Schreiber, Stefan
DOI：
10.1177/17455065211022262
发表时间：
2021-01
期刊：
Women's health (London, England)
影响因子：
--
作者：
Ciarambino T;Para O;Giordano M
通讯作者：
Giordano M
影响因子：
8.9
作者：
Ganesh R;Grach SL;Ghosh AK;Bierle DM;Salonen BR;Collins NM;Joshi AY;Boeder ND Jr;Anstine CV;Mueller MR;Wight EC;Croghan IT;Badley AD;Carter RE;Hurt RT
通讯作者：
Hurt RT
DOI：
10.1016/j.jchf.2021.10.002
发表时间：
2021-12
期刊：
JACC. Heart failure
影响因子：
--
作者：
Mancini DM;Brunjes DL;Lala A;Trivieri MG;Contreras JP;Natelson BH
通讯作者：
Natelson BH
Covid-19和感染后的肌动脑膜炎/慢性疲劳综合征：叙事评论。
影响因子：
5.7
作者：
Poenaru S;Abdallah SJ;Corrales-Medina V;Cowan J
通讯作者：
Cowan J