Chloride cells and osmoregulation.

Chloride cells and osmoregulation.
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氯细胞和渗透压调节。

DOI:
10.1038/ki.1996.225
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发表时间:
1996
影响因子:
19.6
通讯作者:
Zadunaisky,JA
Zadunaisky,JA
中科院分区:
医学1区
文献类型:
--
作者:
Zadunaisky,JA

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氯细胞和渗透压调节。鱼类鳃分泌上皮的氯细胞负责从淡水到海水的过渡,通过响应刺激氯离子分泌的快速信号来适应盐度的增加。本文提供的数据支持以下观点:在过渡期间可测量到的血浆渗透压的瞬时增加是刺激氯离子分泌的原因。在适应海水期间,发现异斜眼鳉鱼(鳉鱼)的血浆最大增加了 65 mOsm。在含有大量氯化物细胞的同种鱼的离体鳃盖上皮膜的基底外侧上,甘露醇诱导的渗透压类似或更大的增加产生了氯化物分泌的刺激,检测为短路电流。氯细胞的收缩会激活 Na-K-2Cl 协同转运蛋白和 Na/H 交换器,并需要顶端氯离子通道的完整性和正常的 Ca 水平。 Cl/HCO3 交换器不参与这种对高盐度的渗透反应。用想象和定量光学研究了氯细胞体积对渗透压的反应。
Chloride cells and osmoregulation.The chloride cells of the gill secretory epithelium of fish that make the transition from fresh water to sea water adapt to the increased salinity by responding to a rapid signal that stimulates chloride secretion. In this paper, data are presented supporting the view that the transient increase in plasma osmolarity that can be measured during the transition is responsible for the stimulation of chloride secretion. A maximal increase of 65 mOsm in the plasma ofFundulus heteroclitus(the killifish) was found during acclimation to sea water. Similar or greater increases of osmolarity induced by mannitol on the basolateral side of isolated opercular epithelial membranes of the same species of fish containing great numbers of chloride cells produced stimulation of chloride secretion detected as the short circuit current. The shrinkage of the chloride cell activates the Na-K-2Cl cotransporter, and the Na/H exchanger and requires the integrity of apical chloride channels and normal levels of Ca. A Cl/HCO3exchanger did not participate in this osmotic response to higher salinity. Chloride cell volume responses to osmolarity were studied with imagine and quantitative optics.
鳃盖上皮:最小的鳃渗透压调节和氯化物分泌的实验模型
DOI: 10.1016/b978-0-12-775280-8.50019-6
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发表时间: 1930-06-01
影响因子: --
作者:
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